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盐酸左布诺洛尔

盐酸左布诺洛尔用途

Levobunolol盐酸盐是一种非选择性的β-阻断剂, 局部用药治疗青光眼。

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盐酸左布诺洛尔名称

[ CAS 号 ]:
27912-14-7

[ 中文名 ]:
盐酸左布诺洛尔

[ 英文名 ]:
Levobunolol hydrochloride

[中文别名 ]:

[英文别名 ]:

gotensin
l-bunololhydrochloride
vistagan
Levobunolol hydrochloride
AG-901
w7000a
betagan
LEVOBUNOLOL HCL

盐酸左布诺洛尔生物活性

[ 描述 ]:

Levobunolol盐酸盐是一种非选择性的β-阻断剂, 局部用药治疗青光眼。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

盐酸左布诺洛尔物理化学性质

[ 沸点 ]:
464.4ºC at 760mmHg

[ 熔点 ]:
209-211°

[ 分子式 ]:
C₁₇H₂₆ClNO₃

[ 分子量 ]:
327.84600

[ 闪点 ]:
234.7ºC

[ 精确质量 ]:
327.16000

[ PSA ]:
58.56000

[ LogP ]:
3.52630

[ 蒸汽压 ]:
2.01E-09mmHg at 25°C

[ 储存条件 ]:
2-8℃

盐酸左布诺洛尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK4402500

CHEMICAL NAME :: 1(2H)-Naphthalenone, 3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)- , hydrochloride, (-)-

CAS REGISTRY NUMBER :: 27912-14-7

LAST UPDATED :: 199309

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H25-N-O3.Cl-H

MOLECULAR WEIGHT :: 327.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980 Volume(issue)/page/year: -,317,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 131 gm/kg/2Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,353,1992 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors Tumorigenic - tumor types after systemic administration not seen spontaneously

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,353,1992