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SKF 77434 hydrobromide

SKF 77434 hydrobromide用途

SKF 77434 hydrobromide 是一种选择性的多巴胺 D1 受体 (dopamine D1 receptor) 部分激动剂。SKF 77434 hydrobromide 具有研究可卡因成瘾的潜力。

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SKF 77434 hydrobromide名称

[ CAS 号 ]:
300561-58-4

[ 英文名 ]:
SKF 77434 hydrobromide

[英文别名 ]:

Atrial natriuretic factor (1-28) (human,porcine)

SKF 77434 hydrobromide生物活性

[ 描述 ]:

SKF 77434 hydrobromide 是一种选择性的多巴胺 D1 受体 (dopamine D1 receptor) 部分激动剂。SKF 77434 hydrobromide 具有研究可卡因成瘾的潜力。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Cohen C, et al. Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology (Berl). 1999 Feb;142(1):102-10.

SKF 77434 hydrobromide物理化学性质

[ 分子式 ]:
C₁₉H₂₂BrNO₂

[ 分子量 ]:
376.29

[ 精确质量 ]:
375.08300

[ PSA ]:
43.70000

[ LogP ]:
4.16980

[ 储存条件 ]:
-20°C，密闭，干燥

SKF 77434 hydrobromideMSDS

详细MSDS(安全技术说明书)

SKF 77434 hydrobromide安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

SKF 77434 hydrobromide文献

Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.

J. Neurosci. 22(22) , 9841-9, (2002)

The dynamics of dopamine receptor signaling efficacy were characterized in developing mice by measuring striatal c-Fos expression after dopaminergic agonist treatment at postnatal day 4 (P4) to P18. C...

Proc. Natl. Acad. Sci. U. S. A. 96(9) , 5280-5, (1999)

To study the physiological and molecular mechanisms of age-related memory loss, we assessed spatial memory in C57BL/B6 mice from different age cohorts and then measured in vitro the late phase of hipp...

Comparison of the D1-dopamine agonists SKF-38393 and A-68930 in neonatal 6-hydroxydopamine-lesioned rats: behavioral effects and induction of c-fos-like immunoreactivity.

J. Pharmacol. Exp. Ther. 262(2) , 855-65, (1992)

Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound beha...

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