刺槐素

刺槐素用途

Robinin 是一种存在于 Vigna unguiculata 叶中的类黄酮。Robinin 抑制 TLR2 和TLR4 的表达上调。Robinin 通过 TLR4/NF-κB 通路改善氧化的低密度脂蛋白 (Ox-LDL) 引起的炎症损伤。

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刺槐素名称

[ CAS 号 ]:
301-19-9

[ 中文名 ]:
刺槐素

[ 英文名 ]:
Robinin

[英文别名 ]:

kaempherol-3-O-robinoside-7-O-rhamnoside
Kaempferol-3-O-gal-rham-7-O-rham
Robinin
Kaempferol 3-Robinoside 7-Rhamnoside
kaempherol-3-O-gal-rha-7-O-rha
Kaempferol-3-O-robinoside-7-O-rhamnoside
EINECS 206-113-3

刺槐素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> Toll样受体(TLR)

研究领域 >> 炎症/免疫

[ 靶点 ]

TLR2

TLR4

[参考文献]

[1]. Janeesh PA, et al. Robinin modulates TLR/NF-κB signaling pathway in oxidized LDL induced human peripheral blood mononuclear cells. Int Immunopharmacol. 2014 Jan;18(1):191-7.

刺槐素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
1064.4±65.0 °C at 760 mmHg

[ 熔点 ]:
194-195ºC

[ 分子式 ]:
C₃₃H₄₀O₁₉

[ 分子量 ]:
740.659

[ 闪点 ]:
335.7±27.8 °C

[ 精确质量 ]:
740.216370

[ PSA ]:
308.12000

[ LogP ]:
0.89

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.728

[ 储存条件 ]:
?20°C

刺槐素MSDS

详细MSDS(安全技术说明书)

刺槐素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2979380

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-galac topyranosyl) oxy)-7-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydrox y-2-(4-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 301-19-9

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C33-H40-O19

MOLECULAR WEIGHT :: 740.73

WISWESSER LINE NOTATION :: T66 BO EVT&J GQ IO- BT6OTJ CQ DQ EQ F1& DO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,223,1979

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刺槐素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

刺槐素上下游产品

刺槐素上游产品

刺槐素下游产品

刺槐素文献

Roles of flavonoids in plant resistance to insects.

Prog. Clin. Biol. Res. 213 , 87-100, (1986)

Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry.

J. Pharm. Biomed. Anal. 55 , 109-113, (2011)

An accurate, precise and sensitive method was developed and validated for the simultaneous quantification of the flavonoid glycoside robinin, and its algycone kaempferol in human breast cancer MCF-7 c...

Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP.

In Vivo 19 , 433-8., (2005)

The effects of various flavonoids and carotenoids on Rhodamine 123 accumulation in multidrug-resistant Colo 320 human colon cancer cells expressing MDR1/LRP were studied. The Colo 205 cell line was us...

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刺槐素