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2,3-二巯基丁二酸

2,3-二巯基丁二酸用途

Succimer 是一种广泛用于治疗铅中毒的螯合剂。

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2,3-二巯基丁二酸名称

[ CAS 号 ]:
304-55-2

[ 中文名 ]:
内消旋-2,3-二巯基丁二酸

[ 英文名 ]:
Succimer

[中文别名 ]:

[英文别名 ]:

Butanedioic acid, 2,3-dimercapto-
(2R,3S)-rel-2,3-Dimercaptosuccinic acid
Butanedioic acid, 2,3-dimercapto-, (R*,S*)-
meso-2,3-diisopropyl-succinic acid
2,3-Disulfanylsuccinic acid
3-dimercaptosuccinic acid
meso-2,3-Dimercaptosuccinic acid
Succinic acid, 2,3-dimercapto-, (±)-
meso-2,3-dimercapto succinic acid
Dimercaptosuccinic acid

2,3-二巯基丁二酸生物活性

[ 描述 ]:

Succimer 是一种广泛用于治疗铅中毒的螯合剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[体内研究]

Succimer是一种广泛用于治疗Pb中毒的螯合剂。与铅组相比,用NAC或Succimer处理的铅暴露动物的红细胞(RBC)显示具有显着更高的谷胱甘肽(GSH)水平和降低的丙二醛(MDA)水平。二聚体给药还导致铅暴露动物的红细胞中葡萄糖6-磷酸脱氢酶(G6PD)活性降低[1]。对于两种铅暴露条件,二巯丁二酸处理都会显着降低血铅水平：高铅琥珀组的血铅水平是治疗结束时高铅组血铅水平的27％。 Succimer可有效减少脑铅,因为高Pb-succ组的脑铅含量是高铅组的37％[2]。

[动物实验]

所有实验均用重量为75至100g的Fisher 344雄性大鼠进行。将动物随机分成四组。组I（n = 11）作为对照，仅给予标准大鼠食物和水6周。第II组（n = 11）在其饮用水中接受2000ppm醋酸铅5周，并且在第6周期间，该组接受水。 III组（n = 6）在其饮用水中接受2000ppm醋酸铅5周，并且在第6周期间，这些动物接受溶解于水中的800mg / kg /天NAC。第IV组（n = 6）与第III组一样，除了在上周接受90mg / kg /天的Succimer。在第6周结束时，在禁食过夜后，用异丙烷麻醉动物，并使用肝素作为抗凝血剂通过心内穿刺收集血液样品。通过以3000rpm离心10分钟除去血浆和血沉棕黄层。用等体积的冷盐水洗涤RBC三次[1]。

[参考文献]

[1]. Gürer H, et al. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology. 1998 Jul 17;128(3):181-9.

[2]. Beaudin SA, et al. Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats. Neurotoxicol Teratol. 2007 Mar-Apr;29(2):188-202.

[相关活性小分子]

2,3-二巯基丁二酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
267.6±40.0 °C at 760 mmHg

[ 熔点 ]:
196-198ºC (dec.)

[ 分子式 ]:
C₄H₆O₄S₂

[ 分子量 ]:
182.218

[ 闪点 ]:
115.6±27.3 °C

[ 精确质量 ]:
181.970749

[ PSA ]:
152.20000

[ LogP ]:
1.93

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.617

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

2,3-二巯基丁二酸MSDS

详细MSDS(安全技术说明书)

2,3-二巯基丁二酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM7650000

CHEMICAL NAME :: Succinic acid, 2,3-dimercapto-, meso-

CAS REGISTRY NUMBER :: 304-55-2

BEILSTEIN REFERENCE NO. :: 1725150

LAST UPDATED :: 199707

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C4-H6-O4-S2

MOLECULAR WEIGHT :: 182.22

WISWESSER LINE NOTATION :: SHYVQYVQSH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5011 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 20,83,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1725 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,283,1961

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,283,1961 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 30,181,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 30,181,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 30,191,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 17600 mg/kg

SEX/DURATION :: female 14-21 day(s) after conception lactating female 14 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 47,1745,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8200 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,715,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 16400 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,715,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 4100 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,715,1988

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2,3-二巯基丁二酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
24/25-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WM7650000

[ 海关编码 ]:
2930909090

2,3-二巯基丁二酸合成路线

详细合成路线

2,3-二巯基丁二酸制备

由二溴丁二酸经消除、加成、水解而得。

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2,3-二巯基丁二酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2,3-二巯基丁二酸文献

A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments.

Nat. Commun. 6 , 6579, (2015)

The volatile compound dimethylsulphide (DMS) is important in climate regulation, the sulphur cycle and signalling to higher organisms. Microbial catabolism of the marine osmolyte dimethylsulphonioprop...

Identification and Characterization of EDTA Test Strip Interfering Substances Using a Digital Color Detector.

Clin. Lab. 61 , 785-91, (2015)

Rapid test strips for ethylenediaminetetraacetic acid (EDTA) can be used to verify correct specimen types for clinical assays which require, or cannot be performed on, plasma collection tubes containi...

How do esters and dimethyl sulphide concentrations affect fruity aroma perception of red wine? Demonstration by dynamic sensory profile evaluation.

Food Chem. 194 , 196-200, (2015)

Our study focused on variations in wine aroma perception and molecular composition during tasting over a period of 30min. In parallel, dynamic analytical and sensory methods were applied to study chan...

更多文献

2,3-二巯基丁二酸

2,3-二巯基丁二酸用途

2,3-二巯基丁二酸名称

2,3-二巯基丁二酸生物活性

2,3-二巯基丁二酸物理化学性质

2,3-二巯基丁二酸MSDS

详细MSDS(安全技术说明书)

2,3-二巯基丁二酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2,3-二巯基丁二酸安全信息

2,3-二巯基丁二酸合成路线

详细合成路线

2,3-二巯基丁二酸制备

2,3-二巯基丁二酸海关

2,3-二巯基丁二酸文献

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