L-肌肽

L-肌肽用途

L-Carnosine 是 beta-丙氨酸和组氨酸组成的二肽,能够抑制许多衰老带来的生化变化。

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L-肌肽作用

肌肽（L-Carnosine），学名β-丙氨酰-L-组氨酸，是由是一种由β-丙氨酸和L-组氨酸两种氨基酸组成的二肽，结晶状固体。肌肉和脑部的组织含有很高浓度的肌肽。肌肽是一种跟肉碱一起由俄国化学家古列维奇发现。在英国、韩国、俄国及其他国家均有研究表明：肌肽具有很强的抗氧化能力，对人体有益。肌肽已被证实可清除在氧化应激过程中使细胞膜的脂肪酸过度氧化而形成的活性氧自由基（ROS）以及α-β不饱和醛。

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L-肌肽名称

[ CAS 号 ]:
305-84-0

[ 中文名 ]:
L-肌肽

[ 英文名 ]:
L-carnosine

[中文别名 ]:

[英文别名 ]:

N-b-Alanyl-L-histidine
EINECS 206-169-9
L-Histidine, N-β-alanyl-
β-Alanyl-L-histidine
N-(b-Alanyl)-L-histidine
N-β-Alanyl-L-histidin
beta-Alanyl-L-histidine
ignotine
n-2-m
L-IGNOTINE

L-肌肽生物活性

[ 描述 ]:

L-Carnosine 是 beta-丙氨酸和组氨酸组成的二肽,能够抑制许多衰老带来的生化变化。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

L-肌肽是氨基酸β-丙氨酸和组氨酸的二肽,有可能抑制伴随衰老的许多生化变化[1]。肌肽还具有一些抗氧化作用。肌肽的抗氧化机制归因于其对金属离子的螯合作用,超氧化物歧化酶(SOD)样活性,以及ROS和自由基清除能力[2]。

[参考文献]

[1]. Hipkiss AR, et al. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74.

[2]. Guney Y, et al. Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses. 2006;66(5):957-9.

[相关活性小分子]

L-肌肽物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
656.2±55.0 °C at 760 mmHg

[ 熔点 ]:
253 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₁₄N₄O₃

[ 分子量 ]:
226.232

[ 闪点 ]:
350.7±31.5 °C

[ 精确质量 ]:
226.106583

[ PSA ]:
121.10000

[ LogP ]:
-2.17

[ 外观性状 ]:
结晶

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
库房低温通风干燥

L-肌肽MSDS

L-肌肽毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MS3080000

CHEMICAL NAME :: L-Histidine, N-beta-alanyl-

CAS REGISTRY NUMBER :: 305-84-0

BEILSTEIN REFERENCE NO. :: 0087671

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H14-N4-O3

MOLECULAR WEIGHT :: 226.27

WISWESSER LINE NOTATION :: T5M CNJ D1YVQMV2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >14930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9087 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 21 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1219,1974

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L-肌肽安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
MS3080000

[ 海关编码 ]:
2933290090

L-肌肽合成路线

L-肌肽上下游产品

L-肌肽上游产品

L-肌肽下游产品

L-肌肽海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-肌肽文献

Hydrogel-based ultra-moisturizing cream formulation for skin hydration and enhanced dermal drug delivery.

Biol. Pharm. Bull. 37(10) , 1674-82, (2014)

To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL,...

Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.

Anal. Sci. 31 , 805-14, (2015)

To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit...

Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry.

Electrophoresis 35(23) , 3321-30, (2014)

There is high interest in the discovery of early diagnostic biomarkers of Alzheimer's disease, for which metabolomics exhibits a great potential. In this work, a metabolomic approach based on ultrafil...

更多文献

L-肌肽

L-肌肽用途

L-肌肽作用

L-肌肽名称

L-肌肽生物活性

L-肌肽物理化学性质

L-肌肽MSDS

详细MSDS(安全技术说明书)

L-肌肽毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

L-肌肽安全信息

L-肌肽合成路线

详细合成路线

L-肌肽上下游产品

L-肌肽上游产品

L-肌肽下游产品

L-肌肽海关

L-肌肽文献

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