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L-组氨酸

L-组氨酸用途

L-Hisidine是婴儿必需的氨基酸。L-Hisidine是线粒体谷氨酰胺转运的抑制剂。

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L-组氨酸名称

[ CAS 号 ]:
71-00-1

[ 中文名 ]:
L-组氨酸

[ 英文名 ]:
L-Histidine

[中文别名 ]:

[英文别名 ]:

(S)-a-Amino-1H-imidazole-4-propanoic Acid
(S)-1H-Imidazole-4-alanine
a-Amino-4(or 5)-Imidazolepropionic Acid
d,l-histidine
1H-Imidazole-4-propanoic acid, α-amino-, (S)-
FEMA 3694
(S)-histidine
EINECS 200-745-3
HISTIDINE, L-
His

L-组氨酸生物活性

[ 描述 ]:

L-Hisidine是婴儿必需的氨基酸。L-Hisidine是线粒体谷氨酰胺转运的抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 线粒体代谢

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

天然产物 >> 其他

[体外研究]

L-组氨酸完全抑制生长,其对生存力的影响与FLO11表达成反比。 L-组氨酸不影响Δflo11和S288c菌株的活力。 L-组氨酸显着降低了flor酵母的气液生物膜形成和与聚苯乙烯的粘附,而对FLO11基因的转录水平没有影响。此外,L-组氨酸可以改变弗洛尔酵母细胞壁上的几丁质和聚糖含量[1]。

[体内研究]

L-组氨酸(100 mg/kg)完全抑制硫代乙酰胺治疗大鼠的脑水肿[2]。在L-组氨酸饮食组中由来自下丘脑的高K +刺激的组胺释放是对照组的60％。然而,L-组氨酸饮食不会改变其他单胺及其代谢物的浓度。野外试验显示,L-组氨酸饮食组在中心区域花费的时间较短,而明/暗盒测试表明L-组氨酸饮食组在灯箱中花费的时间较短,提示L-组氨酸饮食可引起焦虑样行为[3]。

[动物实验]

大鼠：每天给动物施用TAA（300mg / kg ip）3天。在每次TAA注射前2小时，将L-组氨酸（100mg / kg）溶解在盐水中并每天注射（ip）。为防止低血糖和脱水，每12小时给予大鼠12.5ml / kg的液体治疗（5％右旋糖和0.45％盐水，20mEq / L氯化钾），sc标准对照接受盐水（用于TAA的载体），而另一组大鼠每天单独给予L-组氨酸（100mg / kg），持续3天。对TAA治疗的大鼠进行临床监测，并对脑病的阶段进行分级[2]。小鼠：对照组喂食含有5.08克L-组氨酸/ kg的AIN-93G纯化饮食，而L-组氨酸饮食组喂食含有1.28克L-组氨酸/ kg的AIN-93G（25％ AIN-93G中的组氨酸含量。为了平衡氨基酸的总量，将谷氨酰胺添加到L-组氨酸饮食中以抵消组氨酸含量的变化（18.32g L-谷氨酰胺/ kg AIN-93G对比23.72g L-谷氨酰胺/ kg L-组氨酸饮食）。两种饮食都是等氮的。在8周龄时，将小鼠称重并分配给2种不同的饮食。允许小鼠随意获取水及其各自的饮食，并且在开始实验之前将它们在实验室中饲养至少2周[3]。

[参考文献]

[1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141.

[2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8.

[3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41.

[相关活性小分子]

L-组氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
458.9±35.0 °C at 760 mmHg

[ 熔点 ]:
282 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₉N₃O₂

[ 分子量 ]:
155.155

[ 闪点 ]:
231.3±25.9 °C

[ 精确质量 ]:
155.069473

[ PSA ]:
92.00000

[ LogP ]:
-1.26

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
室温

[ 水溶解性 ]:
41.6 g/L (25 ºC)

L-组氨酸MSDS

详细MSDS(安全技术说明书)

L-组氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MS3070000

CHEMICAL NAME :: Histidine, L-

CAS REGISTRY NUMBER :: 71-00-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C6-H9-N3-O2

MOLECULAR WEIGHT :: 155.18

WISWESSER LINE NOTATION :: T5M CNJ E1YZVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 221 gm/kg/46D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - other changes Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/5W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2500 ppm

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 28,117,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4775 No. of Facilities: 233 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 13683 (estimated) No. of Female Employees: 11508 (estimated)

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L-组氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
MS3070000

[ 海关编码 ]:
2933290090

L-组氨酸合成路线

详细合成路线

L-组氨酸上下游产品

L-组氨酸上游产品

L-组氨酸下游产品

L-组氨酸制备

1.从猪血、牛血中提取。猪血经喷雾干燥制得血粉，每100kg猪血约18kg血粉。L-组氨酸常用其盐酸盐（[7048-02-4]）。将含有L-组氨酸的洗脱液，浓缩至出现结晶，趁热用盐酸调至pH为2.5，立即加入2倍于溶液量的乙醇，静置，沉淀，过滤，即得L-组氨酸盐酸盐粗品，经脱色、重结晶、干燥得成品。L-组氨酸也可从脱脂大豆的水解产物中提取。

2.直接发酵法

3. 烟草：BU，22；FC，21。其咪唑易与金属离子形成络盐。

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L-组氨酸海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-组氨酸文献

Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6.

Mol. Plant 7(8) , 1365-83, (2014)

ACCELERATED CELL DEATH6 (ACD6) is a multipass membrane protein with an ankyrin domain that acts in a positive feedback loop with the defense signal salicylic acid (SA). This study implemented biochemi...

G-quadruplex conformation and dynamics are determined by loop length and sequence.

Nucleic Acids Res. 42(12) , 8106-14, (2014)

The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ...

Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

J. Invest. Dermatol. 135(1) , 102-9, (2014)

House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importanc...

更多文献

L-组氨酸

L-组氨酸用途

L-组氨酸名称

L-组氨酸生物活性

L-组氨酸物理化学性质

L-组氨酸MSDS

详细MSDS(安全技术说明书)

L-组氨酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

L-组氨酸安全信息

L-组氨酸合成路线

详细合成路线

L-组氨酸上下游产品

L-组氨酸上游产品

L-组氨酸下游产品

L-组氨酸制备

L-组氨酸海关

L-组氨酸文献

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