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Panepoxydone

Panepoxydone用途

泛环氧酮是NF-κB激活的抑制剂。泛环氧酮通过抑制IκB的磷酸化来干扰NF-κB介导的信号转导。泛环氧酮具有抗肿瘤、抗炎、抗疟疾和抗寄生虫活性[1][2]。

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Panepoxydone名称

[ CAS 号 ]:
31298-54-1

[ 英文名 ]:
Panepoxydone

[英文别名 ]:

SL-3042
Antibiotic SL-3042
Panepoxydone

Panepoxydone生物活性

[ 描述 ]:

泛环氧酮是NF-κB激活的抑制剂。泛环氧酮通过抑制IκB的磷酸化来干扰NF-κB介导的信号转导。泛环氧酮具有抗肿瘤、抗炎、抗疟疾和抗寄生虫活性[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

研究领域 >> 炎症/免疫

[参考文献]

[1]. Arora R, et, al. Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. PLoS One. 2014 Jun 4;9(6):e98370.

[2]. Erkel G, et, al. Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells. Int Immunopharmacol. 2007 May;7(5):612-24.

Panepoxydone物理化学性质

[ 分子式 ]:
C₁₁H₁₄O₄

[ 分子量 ]:
210.22600

[ 精确质量 ]:
210.08900

[ PSA ]:
70.06000

PanepoxydoneMSDS

详细MSDS(安全技术说明书)

Panepoxydone安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

Panepoxydone文献

Tumor necrosis factor (TNF)-α upregulates progesterone receptor-A by activating the NF-κB signaling pathway in human decidua after labor onset.

Placenta 33(1) , 1-7, (2012)

To date, the relationship between inflammatory cytokines and progesterone receptors (PRs) has been little studied, although both mediate the mechanism of parturition in human deciduas. Thus, the aim o...

Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent.

Bioorg. Med. Chem. Lett. 12(23) , 3463-6, (2002)

A number of inhibitors of NF-kappaB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure-activity data have been correlated to allow the desi...

In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy.

Braz. J. Med. Biol. Res. 43(11) , 1054-61, (2010)

Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity on Trypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibit...

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