< 生产厂家价格 >

伊文思蓝

伊文思蓝用途

Evans Blue是一种有效的L-谷氨酸摄取抑制剂, 通过膜结合的兴奋性氨基酸转运蛋白 (EAAT)。能够对抗AMPA红藻氨酸受体介导的电流 (IC50值分别是220和150 nM), 高亲和力与血清白蛋白结合。

点击显示

伊文思蓝名称

[ CAS 号 ]:
314-13-6

[ 中文名 ]:
伊文思蓝

[ 英文名 ]:
Evans Blue

[中文别名 ]:

[英文别名 ]:

evablin
EINECS 206-242-5
evans blue tetrasodium salt
C.I. Direct Blue 53
Diazol Pure Blue BF
azovanblue
MFCD00004021
AZOVAN BLUE
GEIGY BLUE
t1824

伊文思蓝生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

生化试剂

研究领域 >> 其他

[相关活性小分子]

伊文思蓝物理化学性质

[ 分子式 ]:
C₃₄H₂₄N₆Na₄O₁₄S₄

[ 分子量 ]:
960.805

[ 精确质量 ]:
959.982422

[ PSA ]:
404.26000

[ LogP ]:
10.78520

[ 外观性状 ]:
暗棕色

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with strong reducing agents, strong oxidizing agents.

[ 水溶解性 ]:
280 G/L (20 ºC)

伊文思蓝MSDS

详细MSDS(安全技术说明书)

伊文思蓝毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6440000

CHEMICAL NAME :: 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis (4-amino-5-hydroxy-, tetrasodium salt

CAS REGISTRY NUMBER :: 314-13-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C34-H24-N6-O14-S4.4Na

MOLECULAR WEIGHT :: 960.84

WISWESSER LINE NOTATION :: L66J BZ CSWO ESWO JQ INUNR B1 DR C1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mL/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 mL/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg/10D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg/34W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 70 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 70 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 140 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 7-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - hamster Liver

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,151,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,151,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 1,131,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0844 No. of Facilities: 162 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 5350 (estimated) No. of Female Employees: 2829 (estimated)

点击显示

伊文思蓝安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350

[ 警示性声明 ]:
P201-P308 + P313

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R45;R63

[ 安全声明 (欧洲) ]:
53-45-36/37-16-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QJ6440000

伊文思蓝制备

由3，3'-二甲基联苯胺重氮化后与1-氨基-8-萘酚-2，4-二磺酸（1824酸）偶合而得。

点击显示

伊文思蓝文献

Targeting latent TGFβ release in muscular dystrophy.

Sci. Transl. Med. 6(259) , 259ra144, (2014)

Latent transforming growth factor-β (TGFβ) binding proteins (LTBPs) bind to inactive TGFβ in the extracellular matrix. In mice, muscular dystrophy symptoms are intensified by a genetic polymorphism th...

Emilin1 deficiency causes structural and functional defects of lymphatic vasculature.

Mol. Cell. Biol. 28(12) , 4026-39, (2008)

Lymphatic-vasculature function critically depends on extracellular matrix (ECM) and on its connections with lymphatic endothelial cells (LECs). However, the composition and the architecture of ECM hav...

Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.

PLoS ONE 7(12) , e51539, (2012)

Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication. The pathogenesis and underlying mechanisms of septic encephalopathy are not well understood. This study sought...

更多文献

伊文思蓝

伊文思蓝用途

伊文思蓝名称

伊文思蓝生物活性

伊文思蓝物理化学性质

伊文思蓝MSDS

详细MSDS(安全技术说明书)

伊文思蓝毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

伊文思蓝安全信息

伊文思蓝制备

伊文思蓝文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物