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三氟醋柳酸

三氟醋柳酸用途

Triflusal能通过乙酰化COX-1,不可逆地抑制血小板中血栓素B2的产生。

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三氟醋柳酸名称

[ CAS 号 ]:
322-79-2

[ 中文名 ]:
三氟柳

[ 英文名 ]:
Triflusal

[中文别名 ]:

[英文别名 ]:

Triflusal
2-(acetyloxy)-4-(trifluoromethyl)benzoic acid
α,α,α-Trifluoro-2,4-cresotic Acid Acetate
2-Acetoxy-4-trifluoromethylbenzoic acid
EINECS 206-297-5
Triflusalum [INN-Latin]
2-Acetoxy-4-trifluoromethylbenzoicacid
Benzoic acid, 2-(acetyloxy)-4-(trifluoromethyl)-
Triflusal [INN]
2-Acetoxy-4-trifluormethyl-benzoesaeure

三氟醋柳酸生物活性

[ 描述 ]:

Triflusal能通过乙酰化COX-1,不可逆地抑制血小板中血栓素B2的产生。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX-2:280 μM (IC50)

COX-2:160 μM (IC50, in human blood)

[参考文献]

[1]. Fernández de Arriba A, et al. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. Mol Pharmacol. 1999 Apr;55(4):753-60.

[2]. Duran, X., et al., Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. J Thromb Haemost, 2008. 6(8): p. 1385-92.

[3]. De Miguel, L.S., et al., A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. Eur J Clin Invest, 2000. 30(9): p. 811-7.

[相关活性小分子]

三氟醋柳酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
316.0±42.0 °C at 760 mmHg

[ 熔点 ]:
115 °C

[ 分子式 ]:
C₁₀H₇F₃O₄

[ 分子量 ]:
248.155

[ 闪点 ]:
144.9±27.9 °C

[ 精确质量 ]:
248.029648

[ PSA ]:
63.60000

[ LogP ]:
2.90

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.484

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
水溶性：不溶

三氟醋柳酸MSDS

三氟醋柳酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GP4250000

CHEMICAL NAME :: 2,4-Cresotic acid, alpha,alpha,alpha-trifluoro-, acetate

CAS REGISTRY NUMBER :: 322-79-2

BEILSTEIN REFERENCE NO. :: 2945374

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H7-F3-O4

MOLECULAR WEIGHT :: 248.17

WISWESSER LINE NOTATION :: FXFFR DVQ COV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 402 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 217 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 228 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978

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三氟醋柳酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38-43

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
GP4250000

[ 海关编码 ]:
2918990090

三氟醋柳酸合成路线

三氟醋柳酸上下游产品

三氟醋柳酸上游产品

三氟醋柳酸下游产品

三氟醋柳酸海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

三氟醋柳酸文献

Long-term follow-up of atrial fibrillation patients in the NASPEAF study. Prospective evaluation of different antiplatelet treatments.

Rev. Esp. Cardiol. 62(9) , 992-1000, (2009)

In the NASPEAF (National Study for Prevention of Embolism in Atrial Fibrillation) trial, combination therapy with an anticoagulant and an antiplatelet was more effective than anticoagulation alone in ...

Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes.

Comb. Chem. High Throughput Screen 13(7) , 569-77, (2010)

The electrochemical behavior of triflusal (TRF) and aspirin (ASA), before and after hydrolysis in water and in alkaline medium using two different electrode surfaces, glassy carbon and boron doped dia...

A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.

Expert Opin. Drug Metab. Toxicol. 7(12) , 1471-9, (2011)

An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compa...

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