N-叔丁基-α-苯基硝酮

N-叔丁基-α-苯基硝酮用途

N-tert-Butyl-α-phenylnitrone 是一种基于硝酮的自由基清除剂,可形成一氧化氮自旋加合物。N-tert-Butyl-α-phenylnitrone 抑制 COX2 的催化活性。N-tert-Butyl-α-phenylnitrone 具有有效的 ROS 清除,抗炎,神经保护,抗衰老和抗糖尿病的作用,并且可以穿透血脑屏障。

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N-叔丁基-α-苯基硝酮名称

[ CAS 号 ]:
3376-24-7

[ 中文名 ]:
N-叔丁基-α-苯基硝酮

[ 英文名 ]:
n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

[中文别名 ]:

[英文别名 ]:

N-tert-Butyl-alpha-phenylnitrone
phenyl t-butyl nitrone
N-tert-Butyl-α-phenylnitrone
Styryl phenyl sulfone
2-Phenylethenyl phenyl sulfone
MFCD00008799
EINECS 222-168-6
N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide
N-benzylidene-tert-butylamine N-oxide
n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

N-叔丁基-α-苯基硝酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[ 靶点 ]

COX-2

Reactive oxygen species (ROS)

[体外研究]

N-叔丁基-α-苯基硝酮(PBN)(25-100µM)处理可显著降低2,2'-偶氮双(2-氨基丙烷)二盐酸盐(AAPH)诱导的细胞内ROS累积。N-叔丁基-α-苯基硝基酮也能减弱AAPH诱导的细胞毒性、基质降解和凋亡。N-叔丁基-α-苯基硝基酮抑制AAPH诱导的ERK/MAPK通路激活。N-叔丁基-α-苯基亚硝酮对椎间盘退变(IDD)的研究具有潜在意义[1]。

[体内研究]

N-叔丁基-α-苯基亚硝酮(PBN；100mg/kg；腹腔注射；一天两次；C57Bl/6小鼠)治疗不仅可以消除LPS诱导的脂质过氧化、硝基酪氨酸残留水平和GSH耗竭,还可以降低外部畸形的发生率[2]。动物模型：脂多糖(LPS)诱导C57Bl/6小鼠[2]剂量：100mg/kg给药：腹腔注射；每日2次(妊娠第8天)结果：消除LPS诱导的脂质过氧化、硝基酪氨酸残留和GSH耗竭。

[参考文献]

[1]. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10.

[2]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57.

[3]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 19;1448(1):77-84.

[4]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec;222(3):236-45.

N-叔丁基-α-苯基硝酮物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
283.3±23.0 °C at 760 mmHg

[ 熔点 ]:
71-75ºC

[ 分子式 ]:
C₁₁H₁₅NO

[ 分子量 ]:
177.243

[ 闪点 ]:
118.5±15.4 °C

[ 精确质量 ]:
177.115356

[ PSA ]:
28.75000

[ LogP ]:
1.25

[ 外观性状 ]:
powder | white

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: soluble

N-叔丁基-α-苯基硝酮MSDS

详细MSDS(安全技术说明书)

N-叔丁基-α-苯基硝酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TX1760000

[ 海关编码 ]:
2925290090

N-叔丁基-α-苯基硝酮上下游产品

N-叔丁基-α-苯基硝酮上游产品

N-叔丁基-α-苯基硝酮下游产品

N-叔丁基-α-苯基硝酮海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

N-叔丁基-α-苯基硝酮文献

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PLoS ONE 10 , e0136450, (2015)

Quinoxaline 1,4-di-N-oxides (QdNOs) are widely known as potent antibacterial agents, but their antibacterial mechanisms are incompletely understood. In this study, the transcriptomic and proteomic pro...

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