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3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮

3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮用途

EF24是一种姜黄素类似物,通过失活口腔鳞状细胞癌(OSCC)中的MAPK/ERK信号通路,具有更强的抗肿瘤功效和口服生物利用度。EF24处理增加了激活的半胱氨酸蛋白酶3和9的水平,并降低了MEK1和ERK的磷酸化形式[1][2]。

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3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮名称

[ CAS 号 ]:
342808-40-6

[ 中文名 ]:
3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮

[ 英文名 ]:
EF24

[英文别名 ]:

EF-24

3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

信号通路 >> MAPK/ERK信号通路 >> ERK

信号通路 >> 干细胞及 Wnt 通路 >> ERK

[参考文献]

[1]. Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834.

[2]. Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.

3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮物理化学性质

[ 分子式 ]:
C₁₉H₁₆ClF₂NO

[ 分子量 ]:
347.78600

[ 精确质量 ]:
347.08900

[ PSA ]:
29.10000

[ LogP ]:
4.73490

3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮MSDS

3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮合成路线

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3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮文献

Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.

Sci. Rep. 5 , 11836, (2015)

Cantharidin is an active constituent of mylabris, a traditional Chinese medicine, and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in cell cycle co...

Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac.

Cell Cycle 15 , 381-93, (2016)

Previous studies have indicated that inflammatory stimulation represses protein phosphatase 2A (PP2A), a well-known tumor suppressor. However, whether PP2A repression participates in pancreatic cancer...

Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis.

Crit. Care 17 , R199, (2014)

Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis (n = 2) or s...

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