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吲哚菁绿

吲哚菁绿用途

Cardiogreen是一种低毒性荧光剂,广泛用于医学诊断,如确定心输出量,肝功能和肝血流量,以及用于眼科血管造影。

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吲哚菁绿名称

[ CAS 号 ]:
3599-32-4

[ 中文名 ]:
吲哚菁绿

[ 英文名 ]:
Indocyanine Green

[中文别名 ]:

[英文别名 ]:

IR-125,laser grade
Cardio-green
Indocyanine Green
Foxgreen,IC Green,Indocyanine green
MFCD00013078
Cardiogreen,Foxgreen,IC Green
EINECS 222-751-5
Cardiogreen

吲哚菁绿生物活性

[ 描述 ]:

Cardiogreen是一种低毒性荧光剂,广泛用于医学诊断,如确定心输出量,肝功能和肝血流量,以及用于眼科血管造影。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[体外研究]

浓度为1000μg/ mL的心脏光动力疗法(ICG-PDT)诱导HGF细胞中BAX的显着表达;然而,激光照射以及ICG对BCL-2基因的表达没有显着影响[1]。

[参考文献]

[1]. Gharesi S, et al. Effect of photodynamic therapy based on indocyanine green on expression of apoptosis-related genes in human gingival fibroblast cells. Photodiagnosis Photodyn Ther. 2017 Apr 21.

[相关活性小分子]

吲哚菁绿物理化学性质

[ 沸点 ]:
157ºC

[ 熔点 ]:
235 °C

[ 分子式 ]:
C₄₃H₄₇N₂NaO₆S₂

[ 分子量 ]:
774.963

[ 精确质量 ]:
774.277344

[ PSA ]:
137.41000

[ LogP ]:
10.55570

[ 外观性状 ]:
绿色至绿色-棕色粉末

[ 储存条件 ]:
库房低温通风干燥

[ 水溶解性 ]:
slightly soluble

吲哚菁绿MSDS

详细MSDS(安全技术说明书)

吲哚菁绿毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE3150000

CHEMICAL NAME :: 1H-Benz(e)indolium, 2-(7(1,1-dimethyl-3-(4-sulfobutyl)benz(e)indolin-2-yl idene)- 1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, inner salt, sodium salt

CAS REGISTRY NUMBER :: 3599-32-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C43-H48-N2-O6-S2.Na

MOLECULAR WEIGHT :: 776.04

WISWESSER LINE NOTATION :: T C5 B66 FKJ D4SWQ F1 F1 E1U2U2U2- ET C5 B66 FKJ D4SWQ F1 F1 &Q 2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,189,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 44,225,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1558 No. of Facilities: 57 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 172 (estimated)

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吲哚菁绿安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DE3150000

吲哚菁绿制备

由l，1，2-三甲基苯基(e)吲哚为原料制得。

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吲哚菁绿文献

Identification and characterization of epithelial cells derived from human ovarian follicular fluid.

Stem Cell Res. Ther. 6 , 13, (2015)

Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid co...

Distance and plasmon wavelength dependent fluorescence of molecules bound to silica-coated gold nanorods.

ACS Nano 8(8) , 8392-406, (2014)

Plasmonic nanoparticles can strongly interact with adjacent fluorophores, resulting in plasmon-enhanced fluorescence or fluorescence quenching. This dipolar coupling is dependent upon nanoparticle com...

Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy.

ACS Nano 8(11) , 11529-42, (2014)

Near-infrared plasmonic nanoparticles demonstrate great potential in disease theranostic applications. Herein a nanoplatform, composed of mesoporous silica-coated gold nanorods (AuNRs), is tailor-desi...

更多文献

吲哚菁绿

吲哚菁绿用途

吲哚菁绿名称

吲哚菁绿生物活性

吲哚菁绿物理化学性质

吲哚菁绿MSDS

详细MSDS(安全技术说明书)

吲哚菁绿毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

吲哚菁绿安全信息

吲哚菁绿制备

吲哚菁绿文献

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