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马来酸二甲茚定

马来酸二甲茚定用途

马来酸二甲酯是一种具有抗组胺作用的选择性组胺H1拮抗剂。马来酸二甲酯可用于超敏反应的研究[1][2][3]。

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马来酸二甲茚定名称

[ CAS 号 ]:
3614-69-5

[ 中文名 ]:
马来酸二甲茚定

[ 英文名 ]:
UNII:6LL60J9E0O

[英文别名 ]:

Fenistil-retard
Fenistil
Forthistal maleate
Dimethinden maleate
Forhistal maleate
Dimethpyrindene maleate
Dimethindene maleate
Dimetindene maleate
UNII:6LL60J9E0O
SU-6518

马来酸二甲茚定生物活性

[ 描述 ]:

马来酸二甲酯是一种具有抗组胺作用的选择性组胺H1拮抗剂。马来酸二甲酯可用于超敏反应的研究[1][2][3]。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

马来酸二甲辛酯(1-1000μM)以浓度依赖和可逆的方式抑制色甘醇诱导的/格列本脲敏感的K＋电流,IC50值为29.5μM[2]。马来酸二甲酯(1-1000μM)抑制Y-26763诱导的格列本脲敏感K＋电流,IC50值为49μM[2]。

[体内研究]

马来酸二甲辛酯(0.25 mg；腹腔注射一次)影响小鼠伤口愈合[1]。动物模型：伤口愈合的C57BL/6小鼠[1]剂量：0.25 mg给药：腹膜内注射；0.25 mg一次结果：显著延迟皮肤伤口,仅在伤口愈合初期显示伤口闭合受损。

马来酸二甲茚定物理化学性质

[ 沸点 ]:
416.3ºC at 760mmHg

[ 熔点 ]:
159-161℃

[ 分子式 ]:
C₂₄H₂₈N₂O₄

[ 分子量 ]:
408.490

[ 闪点 ]:
205.6ºC

[ 精确质量 ]:
408.204895

[ PSA ]:
90.73000

[ LogP ]:
3.85850

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Slightly soluble in water, soluble in methanol

马来酸二甲茚定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT0830000

CAS REGISTRY NUMBER :: 3614-69-5

LAST UPDATED :: 199106

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2.C4-H4-O4

MOLECULAR WEIGHT :: 408.54

WISWESSER LINE NOTATION :: L56 BHJ C2N1&1 DY1&- BT6NJ &QV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 618 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 888 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961

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马来酸二甲茚定安全信息

[ 危害码 (欧洲) ]:
Xn

[ 海关编码 ]:
2933399090

马来酸二甲茚定海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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