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异丙基-β-D-硫代半乳糖苷(IPTG)

异丙基-β-D-硫代半乳糖苷(IPTG)用途

IPTG 是异乳糖模拟物,能够引起乳糖操纵子的转录过程,因此能够诱导乳糖操纵子下游基因对应蛋白的表达。

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异丙基-β-D-硫代半乳糖苷(IPTG)名称

[ CAS 号 ]:
367-93-1

[ 中文名 ]:
异丙基-beta-D-硫代半乳糖吡喃糖苷

[ 英文名 ]:
Isopropyl-beta-D-thiogalactopyranoside

[中文别名 ]:

[英文别名 ]:

MFCD00063273
isopropyl beta-D-thiogalactopyranoside
Isopropyl-b-D-thiogalactopyranoside
UNII-X73VV2246B
Isopropyl β-D-1-thiogalactopyranoside
propan-2-yl 1-thio-β-D-galactopyranoside
Isopropyl 1-thio-b-D-galactopyranoside
Isopropyl-β-D-thiogalactoside
Isopropyl β-D-thiogalactoside
1-Methylethyl 1-thio-β-D-galactopyranoside

异丙基-β-D-硫代半乳糖苷(IPTG)生物活性

[ 描述 ]:

IPTG 是异乳糖模拟物,能够引起乳糖操纵子的转录过程,因此能够诱导乳糖操纵子下游基因对应蛋白的表达。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

生化试剂

研究领域 >> 其他

[体外研究]

大肠杆菌的IPTG摄取可以与乳糖通透酶的作用无关,因为还涉及其他运输途径。在低浓度时,IPTG通过乳糖通透酶进入细胞,但在高浓度(通常用于蛋白质诱导)时,IPTG可以独立于乳糖通透酶进入细胞[1]。

[参考文献]

[1]. Isopropyl β-D-1-thiogalactopyranoside

[相关活性小分子]

异丙基-β-D-硫代半乳糖苷(IPTG)物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
438.4±45.0 °C at 760 mmHg

[ 熔点 ]:
105 °C

[ 分子式 ]:
C₉H₁₈O₅S

[ 分子量 ]:
238.301

[ 闪点 ]:
218.9±28.7 °C

[ 精确质量 ]:
238.087494

[ PSA ]:
115.45000

[ LogP ]:
-1.01

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.578

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
soluble

异丙基-β-D-硫代半乳糖苷(IPTG)MSDS

详细MSDS(安全技术说明书)

异丙基-β-D-硫代半乳糖苷(IPTG)安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H351

[ 警示性声明 ]:
P281-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R19;R40;R66

[ 安全声明 (欧洲) ]:
S23-S24/25-S36/37-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2932999099

异丙基-β-D-硫代半乳糖苷(IPTG)合成路线

详细合成路线

异丙基-β-D-硫代半乳糖苷(IPTG)上下游产品

异丙基-β-D-硫代半乳糖苷(IPTG)上游产品

异丙基-β-D-硫代半乳糖苷(IPTG)下游产品

异丙基-β-D-硫代半乳糖苷(IPTG)海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

异丙基-β-D-硫代半乳糖苷(IPTG)文献

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

J. Virol. 89(9) , 4918-31, (2015)

The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...

Phospho-tyrosine dependent protein-protein interaction network.

Mol. Syst. Biol. 11(3) , 794, (2015)

Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an establis...

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.

Proc. Natl. Acad. Sci. U. S. A. 112(7) , E747-56, (2015)

The nucleotide cyclic di-3',5'- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP-producing bacteria, al...

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