N-(对甲苯磺酰基)-L-苯丙氨酰甲基氯酮(TPCK)

用途

TPCK(L-1-Tosylamido-2-苯乙基氯甲基酮；L-TPCK)是一种有效的丝氨酸蛋白酶抑制剂,可与HPV-18 E7蛋白的视网膜母细胞瘤蛋白(RB)结合核心反应,并消除其RB结合能力。TPCK能够在加入培养基后修饰活角质形成细胞中的E7蛋白【1】。

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名称

[ CAS 号 ]:
402-71-1

[ 中文名 ]:
甲苯磺酰基-L-氨基联苯氯甲基酮

[ 英文名 ]:
Tosyl phenylalanyl chloromethyl ketone

[中文别名 ]:

[英文别名 ]:

MFCD00000935
TPCK
Tosyl phenylalanyl chloromethyl ketone
EINECS 206-954-6
Tosyl-L-phenylalanyl-chloromethane
N-p-Tosyl-L-phenylalanine chloromethyl ketone
N-Tosyl-L-phenylalanyl Chloromethyl Ketone

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[参考文献]

[1]. H Stöppler, et al. The serine protease inhibitors TLCK and TPCK react with the RB-binding core of HPV-18 E7 protein and abolish its RB-binding capability. Virology. 1996 Mar 15;217(2):542-53.

物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
509.9±60.0 °C at 760 mmHg

[ 熔点 ]:
106-108ºC(lit.)

[ 分子式 ]:
C₁₇H₁₈ClNO₃S

[ 分子量 ]:
351.848

[ 闪点 ]:
262.2±32.9 °C

[ 精确质量 ]:
351.069580

[ PSA ]:
71.62000

[ LogP ]:
3.98

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
DMSO: >10 mg/mL stable for several months at 4°C.

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT5613500

CHEMICAL NAME :: p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-

CAS REGISTRY NUMBER :: 402-71-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H18-Cl-N-O3-S

MOLECULAR WEIGHT :: 351.87

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 160 mg/kg

SEX/DURATION :: female 2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 25,954,1974

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安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 3335

[ WGK德国 ]:
3

[ RTECS号 ]:
XT5613500

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