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去乙酰华蟾毒精

去乙酰华蟾毒精用途

去乙酰华蟾毒精(Desacetylcinobufagin)是一用于微生物转化的天然化合物。

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去乙酰华蟾毒精名称

[ CAS 号 ]:
4026-95-3

[ 中文名 ]:
去乙酰华蟾毒精

[ 英文名 ]:
Deacetylcinobufagin

[中文别名 ]:

[英文别名 ]:

Desacetylcinobufagin
Deacetylcinobufagin
16-deacetylcinobufagin
Deacetylcinobufagine

去乙酰华蟾毒精生物活性

[ 描述 ]:

去乙酰华蟾毒精(Desacetylcinobufagin)是一用于微生物转化的天然化合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 类固醇

研究领域 >> 其他

[参考文献]

[1]. Zhu ZT, et al. Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594. J Asian Nat Prod Res. 2013;15(3):294-9.

[相关活性小分子]

去乙酰华蟾毒精物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
601.9±55.0 °C at 760 mmHg

[ 熔点 ]:
278-280ºC

[ 分子式 ]:
C₂₄H₃₂O₅

[ 分子量 ]:
400.508

[ 闪点 ]:
208.1±25.0 °C

[ 精确质量 ]:
400.224976

[ PSA ]:
83.20000

[ LogP ]:
2.00

[ 蒸汽压 ]:
0.0±3.9 mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
-20°C

去乙酰华蟾毒精毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2963500

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,16-beta-dihydroxy-14,15-beta-epoxy-

CAS REGISTRY NUMBER :: 4026-95-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H32-O5

MOLECULAR WEIGHT :: 400.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 4415 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961