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对苯二异硫氰酸酯

对苯二异硫氰酸酯用途

Bitoscanate (p-Phenylene diisothiocyanate) 是一种治疗钩虫的有机化合物。

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对苯二异硫氰酸酯名称

[ CAS 号 ]:
4044-65-9

[ 中文名 ]:
对苯二异硫氰酸酯

[ 英文名 ]:
p-Phenylene diisothiocyanate

[中文别名 ]:

[英文别名 ]:

Bitoscanate
EINECS 223-741-3
1,4-Diisothiocyanatobenzene,Bitoscanate,PDITC
p-Phenylene diisothiocyanate
MFCD00004811
Benzene 1,4-Diisothiocyanate
1,4-Diisothiocyanatobenzene
1,4-Phenylene Diisothiocyanate

对苯二异硫氰酸酯生物活性

[ 描述 ]:

Bitoscanate (p-Phenylene diisothiocyanate) 是一种治疗钩虫的有机化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Gaitonde BB, et al. Clinical evaluation of a new anthelmintic; phenylene di-iso thiocyanate (Bitoscanate) in hookworm and roundworm infestation. J Trop Med Hyg. 1969 Oct;72(10):253-8.

[相关活性小分子]

对苯二异硫氰酸酯物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
339.4ºC at 760 mmHg

[ 熔点 ]:
129-131 °C(lit.)

[ 分子式 ]:
C₈H₄N₂S₂

[ 分子量 ]:
192.26100

[ 闪点 ]:
167.2ºC

[ 精确质量 ]:
191.98200

[ PSA ]:
88.90000

[ LogP ]:
3.15520

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.000182mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
chloroform: clear

对苯二异硫氰酸酯MSDS

对苯二异硫氰酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX9150000

CHEMICAL NAME :: Isothiocyanic acid, 1,4-phenylenedi-

CAS REGISTRY NUMBER :: 4044-65-9

BEILSTEIN REFERENCE NO. :: 2414340

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H4-N2-S2

MOLECULAR WEIGHT :: 192.26

WISWESSER LINE NOTATION :: SCNR DNCS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting

REFERENCE :: JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year: 72,253,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year: 72,253,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

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对苯二异硫氰酸酯安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H334-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S26-S36/37

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
NX9150000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2930909090

对苯二异硫氰酸酯合成路线

对苯二异硫氰酸酯上下游产品

对苯二异硫氰酸酯上游产品

对苯二异硫氰酸酯下游产品

对苯二异硫氰酸酯海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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