盐酸贝凡洛尔
盐酸贝凡洛尔用途
盐酸贝凡洛尔名称
[ CAS 号 ]:
42864-78-8
[ 中文名 ]:
盐酸贝凡洛尔
[ 英文名 ]:
Bevantolol hydrochloride
[中文别名 ]:
[英文别名 ]:
- UNII:4VB9HU07BC
- Bevantolol Hydrochloride
盐酸贝凡洛尔生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
pKi: 7.83 (β1-adrenergic receptor), 6.9 (α1-adrenergic receptor), 6.23 (β2-adrenergic receptor) and Ca2+[1][2]
[体外研究]
[体内研究]
[参考文献]
盐酸贝凡洛尔物理化学性质
[ 沸点 ]:
518.3°C
[ 分子式 ]:
C20H28ClNO4
[ 分子量 ]:
381.894
[ 精确质量 ]:
381.170685
[ PSA ]:
59.95000
[ LogP ]:
3.77710
[ 储存条件 ]:
室温,干燥
盐酸贝凡洛尔毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB2709000
- CHEMICAL NAME :
- 2-Propanol, 1-((3,4-dimethoxyphenethyl)amino)-3-(m-tolyloxy)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 42864-78-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C20-H27-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 381.94
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,364,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,364,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,364,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 419 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,85,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 16200 mg/kg/52W-C
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,3937,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2730 mg/kg/13W-C
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,3905,1991
盐酸贝凡洛尔安全信息
[ 危害码 (欧洲) ]:
Xi
[ 海关编码 ]:
2922299090
盐酸贝凡洛尔合成路线
盐酸贝凡洛尔上下游产品
盐酸贝凡洛尔上游产品
盐酸贝凡洛尔下游产品
盐酸贝凡洛尔海关
[ 海关编码 ]: 2922299090
[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
相关化工产品/化学物质:
相关药品:
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:1-((3,4-二甲氧基苯乙基)氨基)-3-(间甲苯氧基)丙烷-2-醇盐酸盐
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥758.0/1g
¥318.0/250mg
联系人:刘佳
产品详情:盐酸贝凡洛尔
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥549.0/25mg
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥359.9/1ml
¥583.9/1g
¥280.9/250mg
¥2368.9/5g
联系人:阿拉丁
产品详情:盐酸贝凡洛尔
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