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苯甲酰乌头原碱

苯甲酰乌头原碱用途

Benzoylaconine(Isaconitine; Pikraconitin)是中药附子生物碱。

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苯甲酰乌头原碱名称

[ CAS 号 ]:
466-24-0

[ 中文名 ]:
苯甲酰乌头原碱

[ 英文名 ]:
benzoylaconine

[英文别名 ]:

Pikraconitin
Picraconitine
enzoylaconitine
8-O-deacetylaconitine
Isaconitine
14-O-Benzoylaconine
benzoylaconine
Benzoylaconitine
Aconine 14-benzoate

苯甲酰乌头原碱生物活性

[ 描述 ]:

Benzoylaconine(Isaconitine; Pikraconitin)是中药附子生物碱。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 其他

[参考文献]

[1]. Liu XX, et al. Determination of alkaloids in Radix Aconiti Lateralis Preparata by RP-ion-pair HPLC. Yao Xue Xue Bao. 2006 Apr;41(4):365-9.

[2]. Borcsa B, et al. Diterpene alkaloids from the roots of Aconitum moldavicum and assessment of Nav1.2 sodium channel activity of aconitum alkaloids. Planta Med. 2014 Feb;80(2-3):231-6.

[相关活性小分子]

苯甲酰乌头原碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
711.4±60.0 °C at 760 mmHg

[ 熔点 ]:
130°C

[ 分子式 ]:
C₃₂H₄₅NO₁₀

[ 分子量 ]:
603.700

[ 闪点 ]:
384.0±32.9 °C

[ 精确质量 ]:
603.304321

[ PSA ]:
147.38000

[ LogP ]:
0.90

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.631

苯甲酰乌头原碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7849250

CHEMICAL NAME :: Picraconitine

CAS REGISTRY NUMBER :: 466-24-0

BEILSTEIN REFERENCE NO. :: 0073066

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C32-H45-N-O10

MOLECULAR WEIGHT :: 603.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,324,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 19,641,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,324,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,324,1955

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苯甲酰乌头原碱

苯甲酰乌头原碱用途

苯甲酰乌头原碱名称

苯甲酰乌头原碱生物活性

苯甲酰乌头原碱物理化学性质

苯甲酰乌头原碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

苯甲酰乌头原碱上下游产品

苯甲酰乌头原碱上游产品

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