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长春布宁

长春布宁用途

Vincamone是长春花生物碱和长春胺的代谢物, 是一种血管扩张剂。

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长春布宁名称

[ CAS 号 ]:
4880-88-0

[ 中文名 ]:
(-)-象牙(洪达木)酮宁

[ 英文名 ]:
Vinburnine

[中文别名 ]:

长春布宁

[英文别名 ]:

Eburnamenin-14-one, 14,15-dihydro-, (3α,16α)-
(3α,16α)-14,15-Dihydroeburnamenin-14-one
3a,16a-Eburnamonine
vinburnine
(-)-EBURNAMONINE
(3a,16a)-Eburnamenin-14(15H)-one
Eburnamenin-14(15H)-one, (3α,16α)-
Vincamone
MFCD00064309
16-Oxoeburnane

长春布宁生物活性

[ 描述 ]:

Vincamone是长春花生物碱和长春胺的代谢物, 是一种血管扩张剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[相关活性小分子]

长春布宁物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
441.9±33.0 °C at 760 mmHg

[ 熔点 ]:
174-177 °C(lit.)

[ 分子式 ]:
C₁₉H₂₂N₂O

[ 分子量 ]:
294.391

[ 闪点 ]:
221.0±25.4 °C

[ 精确质量 ]:
294.173218

[ PSA ]:
25.24000

[ LogP ]:
3.79

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.719

[ 储存条件 ]:
-20℃

长春布宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YY8575570

CHEMICAL NAME :: Vincamone

CAS REGISTRY NUMBER :: 4880-88-0

LAST UPDATED :: 199703

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2-O

MOLECULAR WEIGHT :: 294.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978

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长春布宁安全信息

[ 安全声明 (欧洲) ]:
S22-S24/25

[ WGK德国 ]:
2

[ RTECS号 ]:
YY8575570

[ 海关编码 ]:
2933990090

长春布宁合成路线

详细合成路线

长春布宁上下游产品

长春布宁上游产品

长春布宁下游产品

长春布宁海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%