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酪胺

酪胺用途

Tyramine是非直接作用的交感神经胺,能从突出前神经末梢释放去甲肾上腺素。

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酪胺名称

[ CAS 号 ]:
51-67-2

[ 中文名 ]:
4-羟基苯乙胺

[ 英文名 ]:
Tyramine

[中文别名 ]:

[英文别名 ]:

Phenol, 4-(ethylamino)-
Uteramine
Tyramin
MFCD00008193
4-Ethylaminophenol
Tocosine
4-(2-aminoethyl)phenol
4-(2-aminoethyl)-pheno
p-Hydroxyphenylethylamine
Tyrosamine

酪胺生物活性

[ 描述 ]:

Tyramine是非直接作用的交感神经胺,能从突出前神经末梢释放去甲肾上腺素。

[ 相关类别 ]:

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

酪胺是一种间接作用的拟交感神经胺,可从突触前神经末梢释放去甲肾上腺素[1]。酪胺可增强去甲肾上腺素对大鼠皮质神经元放电的突触后抑制作用[2]。尽管酪胺以三种异构体形式存在,但是异构体和异构体以非常低的浓度存在,并且当参考酪胺时它是暗示的对映异构体。酪胺通常以脑组织中的纳克/克浓度存在,但它们具有非常快速的周转。酪胺的CNS作用尚不清楚,有人提出它参与多巴胺合成的调节,也可能调节去甲肾上腺素的转换[3]。

[参考文献]

[1]. Harrison WM, et al. The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry. 1984 Jul;41(7):681-5.

[2]. BURN JH, et al. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314-36.

[3]. Juorio AV, et al. A possible role for tyramines in brain function and some mental disorders. Gen Pharmacol. 1982;13(3):181-3.

[相关活性小分子]

酪胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
275.1±23.0 °C at 760 mmHg

[ 熔点 ]:
160-162 °C(lit.)

[ 分子式 ]:
C₈H₁₁NO

[ 分子量 ]:
137.179

[ 闪点 ]:
141.3±13.3 °C

[ 精确质量 ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
1.38

[ 外观性状 ]:
黄色至棕色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
Refrigerator, Under Inert Atmosphere

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

[ 水溶解性 ]:
1g/95mL (15 ºC)

酪胺MSDS

详细MSDS(安全技术说明书)

酪胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ5950000

CHEMICAL NAME :: Phenol, p-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 51-67-2

BEILSTEIN REFERENCE NO. :: 1099914

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: Z2R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 229 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracervical

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,19,1990

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酪胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SJ5950000

[ 海关编码 ]:
2922299090

酪胺合成路线

详细合成路线

酪胺上下游产品

酪胺上游产品

酪胺下游产品

酪胺制备

1. 本品为酪氨酸脱羧产物，存在于腐败的动物组织、成熟的干酪以及麦角中。将酪氨酸经分解或用腐败菌作用制取。也可将对羟基苯基乙腈还原以制取之。

2. 烟草：OR，27。

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酪胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

酪胺文献

Regulators of autophagosome formation in Drosophila muscles.

PLoS Genet. 11(2) , e1005006, (2015)

Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role...

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...

Mixed alkyl aryl phosphonate esters as quenched fluorescent activity-based probes for serine proteases.

Org. Biomol. Chem. 13(8) , 2293-9, (2015)

Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging, ...

更多文献

酪胺

酪胺用途

酪胺名称

酪胺生物活性

酪胺物理化学性质

酪胺MSDS

详细MSDS(安全技术说明书)

酪胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

酪胺安全信息

酪胺合成路线

详细合成路线

酪胺上下游产品

酪胺上游产品

酪胺下游产品

酪胺制备

酪胺海关

酪胺文献

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