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(S)-(+)-布洛芬

(S)-(+)-布洛芬用途

【用途一】
用作解热镇痛药

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(S)-(+)-布洛芬名称

[ CAS 号 ]:
51146-56-6

[ 中文名 ]:
(S)-(+)-布洛芬

[ 英文名 ]:
(S)-(+)-Ibuprofen

[中文别名 ]:

[英文别名 ]:

(2S)-2-(4-Isobutylphenyl)propanoic acid
(S)-(+)-4-Isobutyl-α-methylphenylacetic Acid
(S)-2-(4-Isobutylphenyl)propanoic acid
(+)-(S)-Ibuprofen
(+)-ibuprofen
MFCD00069289
Dexibuprofen
(S)-4-Isobutyl-α-methylphenylacetic acid
(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
(S)-(+)-Ibuprofen

(S)-(+)-布洛芬生物活性

[ 描述 ]:

S(+)-Ibuprofen能抑制COX,对COX1和COX2的IC50分别为13 uM和370 uM。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[相关活性小分子]

(S)-(+)-布洛芬物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
319.6±11.0 °C at 760 mmHg

[ 熔点 ]:
49-53ºC

[ 分子式 ]:
C₁₃H₁₈O₂

[ 分子量 ]:
206.281

[ 闪点 ]:
216.7±14.4 °C

[ 精确质量 ]:
206.130676

[ PSA ]:
37.30000

[ LogP ]:
3.72

[ 外观性状 ]:
无色,结晶固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.519

[ 储存条件 ]:
2~8°C，密封，避光

(S)-(+)-布洛芬MSDS

(S)-(+)-布洛芬安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R63

[ 安全声明 (欧洲) ]:
S36/37-S45

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2916399090

(S)-(+)-布洛芬合成路线

(S)-(+)-布洛芬上下游产品

(S)-(+)-布洛芬上游产品

(S)-(+)-布洛芬下游产品

(S)-(+)-布洛芬制备

1. (+)-(s)-布洛芬·(-)-葡辛胺的制备

在反应瓶中加入消旋布洛芬206g(1mol)和乙醇95%(2000ml),搅拌溶解,加入(-)-葡辛胺146.5,(0.5mol)搅拌回流0.5h.成澄清溶液,冷至室温过夜.析出晶体,过滤,用95%乙醇200ml洗滤饼,抽干,干燥得(+)-(s)-布洛芬·(-)-葡辛胺190g,以消旋布洛芬计收率76%,mp131~134 ºC.

2. (+)-(s)-布洛芬的制备

在反应瓶中加入(+)-(s)-布洛芬·(-)-葡辛胺190g(0.381mol)和5%KOH溶液600ml,于45 ºC搅拌30min.冷至室温,析出固体.过滤,水200ml洗,干燥,得回收葡辛胺110g.合并滤液及洗液,酸化,过滤、水洗、干燥.再以乙醇重结晶,真空下40 ºC干燥得(+)-(s)-布洛芬72g,以消旋布洛芬计,一次拆分收率为70%,mp50~51ºC.

3. 消旋布洛芬回收

在反应瓶中加入过滤出(+)-(s)-布洛芬后的母液及洗液加热,减压浓缩至干,加入10%NaOH600ml,于45ºC搅拌30min, 产生白色沉淀,过滤,50ml水洗,抽干,干燥得回收葡辛胺23g,将母液加到高压釜于600kPa的压力条件下加热6h.降温出料,加盐酸酸化至pH4.过滤,干燥,得消旋布洛芬118g,以母液及洗液中所含左旋及少量消旋布洛芬计,消旋体的回收率为92%,mp73.5~76 ºC.

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(S)-(+)-布洛芬海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

(S)-(+)-布洛芬文献

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The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.

SAAD Dig. 29 , 70-81, (2013)

Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.

J. Pharmacol. Exp. Ther. 351(1) , 61-6, (2014)

Esterase hydrolysis of drugs can accelerate their elimination, thereby limiting their efficacy. Polyethylene glycol (PEG) covalently attached to drugs (pegylation) is known to improve the efficiency o...

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