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盐酸氟哌噻吨

盐酸氟哌噻吨用途

cis-(Z)-Flupentixol dihydrochloride 是有效、选择性的多巴胺DA D1/D2 受体的拮抗剂,其对D2 受体和 5-HT2A 的 Ki 值分别为 0.38 nM 和 7 nM。

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盐酸氟哌噻吨名称

[ CAS 号 ]:
51529-01-2

[ 中文名 ]:
盐酸氟哌噻吨

[ 英文名 ]:
cis-(Z)-Flupentixol dihydrochloride

[中文别名 ]:

[英文别名 ]:

cis-Flupentixol Hydrochloride
FUPENTIXOL DIHYDROCHLORIDE
FLUPENTIXOL DIHYDROCHLORIDE
a-Flupenthixol Hydrochloride
Zimelidine dihydrochloride
Fupentixol HCl
Metamin
Fluanxol dihydrochloride
flupentixolhydrochloride
fx703

盐酸氟哌噻吨生物活性

[ 描述 ]:

cis-(Z)-Flupentixol dihydrochloride 是有效、选择性的多巴胺DA D1/D2 受体的拮抗剂,其对D2 受体和 5-HT2A 的 Ki 值分别为 0.38 nM 和 7 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[ 靶点 ]

D2 Receptor:0.38 nM (Ki)

5-HT2A Receptor:7 nM (Ki)

[体内研究]

顺式-(Z)-氟哌替索(0.25或0.5 mg/kg,i.p.)预处理剂量依赖性地降低可卡因诱导的活性[1]。动物模型：大鼠[1]。剂量：0.125、0.25或0.5mg/kg。管理：IP。结果：可卡因诱导的活性降低。

[参考文献]

[1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.

[2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.

盐酸氟哌噻吨物理化学性质

[ 沸点 ]:
554.7ºC at 760 mmHg

[ 熔点 ]:
194-202ºC

[ 分子式 ]:
C₂₃H₂₇Cl₂F₃N₂OS

[ 分子量 ]:
507.440

[ 闪点 ]:
289.3ºC

[ 精确质量 ]:
506.117310

[ PSA ]:
52.01000

[ LogP ]:
6.08150

[ 外观性状 ]:
white to off-white

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
H2O: soluble

盐酸氟哌噻吨MSDS

详细MSDS(安全技术说明书)

盐酸氟哌噻吨安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P261-P280-P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36/37/39

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
TL9900000

[ 海关编码 ]:
2942000000

盐酸氟哌噻吨海关

[ 海关编码 ]: 2942000000

盐酸氟哌噻吨文献

Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors.

PLoS Negl. Trop. Dis. 9(3) , e0003515, (2015)

New mode-of-action insecticides are sought to provide continued control of pesticide resistant arthropod vectors of neglected tropical diseases (NTDs). We previously identified antagonists of the AaDO...

The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection.

Behav. Pharmacol. 26(1-2) , 193-9, (2014)

The reinforcing and addictive properties of cocaine are thought to rely on the dopaminergic innervation of the striatum. The ventromedial [i.e. nucleus accumbens shell (NAcc) shell] and dorsolateral [...

A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.

Sci. Transl. Med. 7 , 290ra89, (2015)

Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing...

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