< 生产厂家价格 >

SIS3

SIS3用途

SIS3是一个强的和选择性的Smad3抑制剂，也是强的Nox4启动子的调节器。

点击显示

SIS3名称

[ CAS 号 ]:
521984-48-5

[ 中文名 ]:
SIS3

[ 英文名 ]:
SIS3

[英文别名 ]:

SIS3生物活性

[ 描述 ]:

SIS3是可渗透细胞,选择性的 Smad3 抑制剂。它抑制Smad3磷酸化的IC50 为3 µM。

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> TGF-β/Smad蛋白

信号通路 >> TGF-beta/Smad 信号通路 >> TGF-β/Smad蛋白

研究领域 >> 癌症

[参考文献]

[1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82.

[2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.

[3]. Di Bernardini E et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways. J Biol Chem. 2014 Feb 7;289(6):3383-93.

[相关活性小分子]

SIS3物理化学性质

[ 沸点 ]:
737.2ºC at 760 mmHg

[ 分子式 ]:
C₂₈H₂₈ClN₃O₃

[ 分子量 ]:
489.993

[ 闪点 ]:
399.7ºC

[ 精确质量 ]:
489.181915

[ PSA ]:
56.59000

[ LogP ]:
5.59550

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

SIS3MSDS

详细MSDS(安全技术说明书)

SIS3安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

SIS3文献

AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway.

PLoS ONE 9(12) , e114287, (2014)

Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT) to TGF...

Cyclosporine A induces connective tissue growth factor expression in human gingival fibroblasts: suppression by epigallocatechin-3-gallate.

J. Formos. Med. Assoc. 113(11) , 828-32, (2014)

Transforming growth factor-β (TGF-β) plays an important role in the pathogenesis of cyclosporine A (CsA)-induced gingival overgrowth (GO). Connective tissue growth factor (CTGF/CCN2) acts as a cofacto...

Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1.

Arthritis. Res. Ther. 16(2) , R86, (2014)

Although the pathogenesis of systemic sclerosis (SSc) still remains unknown, recent studies have demonstrated that endothelins are deeply involved in the developmental process of fibrosis and vasculop...

更多文献