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地喹氯铵

地喹氯铵用途

Dequalinium氯化物是apamin敏感型的钾离子通道选择性阻断剂。

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地喹氯铵名称

[ CAS 号 ]:
522-51-0

[ 中文名 ]:
地喹氯铵

[ 英文名 ]:
Dequalinium Chloride

[中文别名 ]:

[英文别名 ]:

DECA
efisol
dekamin
evazol
le chlorure de dequalinium
dekadin
EINECS 208-330-9
BADQ-10
dequadin
eriosept

地喹氯铵生物活性

[ 描述 ]:

Dequalinium氯化物是apamin敏感型的钾离子通道选择性阻断剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 感染

[参考文献]

[1]. Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10.

[2]. Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82(3): p. 231-5.

[相关活性小分子]

地喹氯铵物理化学性质

[ 熔点 ]:
≥300 °C(lit.)

[ 分子式 ]:
C₃₀H₄₀Cl₂N₄

[ 分子量 ]:
527.571

[ 精确质量 ]:
526.263000

[ PSA ]:
59.80000

[ LogP ]:
1.34060

[ 外观性状 ]:
粉末

[ 储存条件 ]:
2-8°C

地喹氯铵MSDS

详细MSDS(安全技术说明书)

地喹氯铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA0700000

CHEMICAL NAME :: Quinaldinium, 1,1'-decamethylenebis(4-amino-, dichloride

CAS REGISTRY NUMBER :: 522-51-0

LAST UPDATED :: 199603

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C30-H40-N4.2Cl

MOLECULAR WEIGHT :: 527.64

WISWESSER LINE NOTATION :: T66 BKJ C1 EZ B10- BT66 BKJ C1 EZ &Q 2 &G 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18300 ug/kg

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 82,231,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg/15W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 82,231,1993

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地喹氯铵安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VA0700000

[ 海关编码 ]:
2933499090

地喹氯铵海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

地喹氯铵文献

Antimicrobial topical agents used in the vagina.

Curr. Probl. Dermatol. 40 , 36-47, (2011)

Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effecti...

Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.

Leuk. Res. 38(7) , 795-803, (2014)

Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxi...

N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.

J. Pharmacol. Sci. 118(2) , 156-60, (2012)

Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first characterized nearly 50 years ago, the identity of the mechanism that mediates these actions has not been elucidated. ...

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