< 生产厂家价格 >

盐酸地哌冬

盐酸地哌冬用途

Diperodon是一种局部麻醉剂, 通过在血清分解酶分解而发挥作用。

点击显示

盐酸地哌冬名称

[ CAS 号 ]:
537-12-2

[ 中文名 ]:
盐酸地哌冬

[ 英文名 ]:
Diperodon (hydrochloride)

[英文别名 ]:

Diperocaine
EINECS 208-659-8
Proctodon
Diperodon HCl
DIPERODON HYDROCHLORIDE
Diothane hydrochloride
Diperdon hydrochloride
Diperodon (hydrochloride)

盐酸地哌冬生物活性

[ 描述 ]:

Diperodon是一种局部麻醉剂, 通过在血清分解酶分解而发挥作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Cizmárik J, et al. Study of local anaesthetics. Part 133. Determination of diperodon in blood serum in vitro by the HPLC method. Acta Pol Pharm. 1996 May-Jun;53(3):167-169.

[相关活性小分子]

盐酸地哌冬物理化学性质

[ 沸点 ]:
502ºC at 760mmHg

[ 分子式 ]:
C₂₂H₂₈ClN₃O₄

[ 分子量 ]:
433.92800

[ 闪点 ]:
257.4ºC

[ 精确质量 ]:
433.17700

[ PSA ]:
79.90000

[ LogP ]:
5.22420

[ 储存条件 ]:
-20°C，密闭，干燥

盐酸地哌冬MSDS

详细MSDS(安全技术说明书)

盐酸地哌冬毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1101000

CHEMICAL NAME :: 1,2-Propanediol, 3-piperidino-, dicarbanilate, hydrochloride

CAS REGISTRY NUMBER :: 537-12-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H27-N3-O4.Cl-H

MOLECULAR WEIGHT :: 433.98

WISWESSER LINE NOTATION :: T6NTJ A1YOVMR&&1OVMR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 890 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,398,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,255,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,255,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,255,1933

点击显示

盐酸地哌冬安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TZ1101000

[ 海关编码 ]:
2933399090

盐酸地哌冬海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸地哌冬文献

Study of local anaesthetics. Part 133. Determination of diperodon in blood serum in vitro by the HPLC method.

Acta Pol. Pharm. 53(3) , 167-9, (1996)

A local anaesthetics diperodon by the action of hydrolazes in blood serum is decomposed. A method for its determination in blood serum in vitro has been worked out. It was found that during the first ...

[HPLC determination of diperodon enantiomers in blood serum by using teicoplanin chiral stationary phase].

Ceska. Slov. Farm. 53(5) , 225-7, (2004)

The chiral stationary phase on the base of teicoplanin and the polar-organic mobile phase methanol/acetonitrile/acetic acid/triethylamine 45/55/0.3/0.2 was used for the separation of diperodon enantio...

In vitro study of enzymatic hydrolysis of diperodon enantiomers in blood serum by two-dimensional LC.

J. Pharm. Biomed. Anal. 30(3) , 875-80, (2002)

An on-line coupled HPLC system is described for the determination of the enantiomers of diperodon in blood serum. The method involves three steps: (i) off-line preconcentration and clean-up, (ii) sepa...

更多文献