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奥芬达唑

奥芬达唑用途

Oxfendazole是fenbendazole的亚砜形式,能抗寄生虫。
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奥芬达唑名称

[ CAS 号 ]:
53716-50-0

[ 中文名 ]:
奥吩达唑

[ 英文名 ]:
Oxfendazole

[中文别名 ]:

[英文别名 ]:

奥芬达唑生物活性

[ 描述 ]:

Oxfendazole是fenbendazole的亚砜形式,能抗寄生虫。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物
研究领域 >> 感染

[参考文献]

[1]. http://www.chemicalland21.com/lifescience/phar/OXFENDAZOLE.htm

[2]. Alvarez, L., et al., Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs. Veterinary parasitology, 2013. 194(1): p. 70-74.


[相关活性小分子]

硫酸羟基氯喹 | 甲硝唑 | Emetine dihydrochloride hydrate | 伊维菌素 | 青蒿素 | 盐酸左旋咪唑 | 氟雷拉纳 | RRX-001 | 阿维菌素 | 奎尼丁 | 硫双二氯酚 | 氟苯咪唑 | 甲苯咪唑 | SQ109 | 蒿甲醚

奥芬达唑物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
253ºC

[ 分子式 ]:
C15H13N3O3S

[ 分子量 ]:
315.347

[ 精确质量 ]:
315.067749

[ PSA ]:
103.29000

[ LogP ]:
1.36

[ 外观性状 ]:
白色至淡黄色粉末

[ 折射率 ]:
1.736

[ 储存条件 ]:
2-8°C

奥芬达唑MSDS

详细MSDS(安全技术说明书)

奥芬达唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FD0808000
CHEMICAL NAME :
Carbamic acid, (5-(phenylsulfinyl)-1H-benzimidazol-2-yl)-, methyl ester
CAS REGISTRY NUMBER :
53716-50-0
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C15-H13-N3-O3-S
MOLECULAR WEIGHT :
315.37
WISWESSER LINE NOTATION :
T56 BM DNJ CMVO1 HSO&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
126 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22500 ug/kg
SEX/DURATION :
female 17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22500 ug/kg
SEX/DURATION :
female 17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - live birth index (measured after birth)

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
2 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
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奥芬达唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
FD0835000

奥芬达唑合成路线

详细合成路线

奥芬达唑上下游产品

奥芬达唑上游产品

奥芬达唑下游产品

奥芬达唑制备

由5-苯亚砜基邻苯二胺与1，3-双（甲搓在羰基）-S-甲硫基异硫脲环合制得。收率95%。或由苯硫苯咪唑用双氧水或过氧乙酸氧化制得。

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奥芬达唑文献

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

The effect of feed intake on the rate of flow of digesta and the disposition and activity of oxfendazole in sheep.

Int. J. Parasitol. 23(4) , 477-84, (1993)

Within 3 h of intra-ruminal (IR) administration oxfendazole (OFZ) was extensively associated with digesta particulate material. This association appeared to be a passive adsorption/desorption since sh...

Preparation, characterization and application of a new stir bar sorptive extraction based on poly(vinylphthalimide-co-N,N'-methylenebisacrylamide) monolith.

J. Sep. Sci. 34(23) , 3418-25, (2011)

In this study, a new stir bar sorptive extraction (SBSE) coating based on poly(vinylphthalimide-co-N,N'-methylenebisacrylamide) monolith (SBSE-VPMB) was prepared. The influences of the contents of mon...


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产品详情：[Perfemiker]奥芬达唑,98%

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