< 生产厂家价格 >

1,3,7-三甲基尿酸

1,3,7-三甲基尿酸用途

1,3,7-三甲基尿酸是咖啡因的代谢产物。1,3,7-三甲基尿酸与咖啡因的代谢比率可以作为一种生物标记物来评估,以描述队列中CYP3A活性的变异性[1]。

点击显示

1,3,7-三甲基尿酸名称

[ CAS 号 ]:
5415-44-1

[ 中文名 ]:
1,3,7-三甲基尿酸

[ 英文名 ]:
1,3,7-Trimethyluric acid

[英文别名 ]:

Uric acid, 1,3,7-trimethyl- (VAN) (8CI)
Trimethyluric acid
uric acid, 1,3,7-trimethyl-
BA 2753
1,3,7-trimethylurate
1,3,7-Trimethyl-harnsaeure
1,3,7-Trimethyluric acid
2,6,8-Trihydroxy-1,3,7-trimethylpurine
1,3,7-trimethyl-7,9-dihydro-3H-purine-2,6,8-trione
8-oxy-caffeine

1,3,7-三甲基尿酸生物活性

[ 描述 ]:

1,3,7-三甲基尿酸是咖啡因的代谢产物。1,3,7-三甲基尿酸与咖啡因的代谢比率可以作为一种生物标记物来评估,以描述队列中CYP3A活性的变异性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Y Benchekroun, et al. Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. J Chromatogr B Biomed Sci Appl. 1997 Jan 24;688(2):245-54.

[2]. Madelé van Dyk, et al. Identification of the caffeine to trimethyluric acid ratio as a dietary biomarker to characterise variability in cytochrome P450 3A activity. Eur J Clin Pharmacol. 2019 Sep;75(9):1211-1218.

1,3,7-三甲基尿酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
476.7ºC at 760mmHg

[ 熔点 ]:
≥300ºC

[ 分子式 ]:
C₈H₁₀N₄O₃

[ 分子量 ]:
210.190

[ 闪点 ]:
242.1ºC

[ 精确质量 ]:
210.075287

[ PSA ]:
81.79000

[ LogP ]:
0.06

[ 折射率 ]:
1.661

[ 储存条件 ]:
-20°C，密闭，干燥

1,3,7-三甲基尿酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0783750

CHEMICAL NAME :: 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-1,3,7-trimethyl-

CAS REGISTRY NUMBER :: 5415-44-1

LAST UPDATED :: 199403

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H10-N4-O3

MOLECULAR WEIGHT :: 210.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-43463

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-43463

点击显示

1,3,7-三甲基尿酸安全信息

[ 海关编码 ]:
2933990090

1,3,7-三甲基尿酸合成路线

详细合成路线

1,3,7-三甲基尿酸上下游产品

1,3,7-三甲基尿酸上游产品

1,3,7-三甲基尿酸下游产品

1,3,7-三甲基尿酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%