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双甘肽

双甘肽用途

Glycylglycine 是最简单的多肽,可作为谷氨酰胺 (gamma-glutamyl) 的受体。

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双甘肽名称

[ CAS 号 ]:
556-50-3

[ 中文名 ]:
双甘肽

[ 英文名 ]:
H-Gly-Gly-OH

[中文别名 ]:

[英文别名 ]:

2-(2-AMINOTHIAZOL-4-YL) GLYOXYLIC ACID
(2-amino-thiazol-4-yl)-oxo-acetic acid
ATGA:2-(2-AMINOTHIAZOL-4-YL) GLYOXYLIC ACID
Glycyl-glycine
Glycine, glycyl-
2-(2-Aminothiazol-4-yl)-2-oxoacetic acid
N-Glycylglycine
Glycylglycine
H-Gly-Gly-OH
glycine anhydride

双甘肽生物活性

[ 描述 ]:

Glycylglycine 是最简单的多肽,可作为谷氨酰胺 (gamma-glutamyl) 的受体。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Glycylglycine

[相关活性小分子]

双甘肽物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
453.2±30.0 °C at 760 mmHg

[ 熔点 ]:
220-240 °C (dec.)

[ 分子式 ]:
C₄H₈N₂O₃

[ 分子量 ]:
132.118

[ 闪点 ]:
227.9±24.6 °C

[ 精确质量 ]:
132.053497

[ PSA ]:
92.42000

[ LogP ]:
-1.85

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.505

[ 储存条件 ]:
-15°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

双甘肽MSDS

双甘肽安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S24/25-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2924199090

双甘肽合成路线

双甘肽上下游产品

双甘肽上游产品

双甘肽下游产品

双甘肽制备

制备方法：由甘氨酸缩合、分解而得。将甘氨酸与乙二胺按1：56混合，搅拌下于174-176℃保温50min，然后于冰室中放置20h，过滤后加水加热将甘氨酰酐溶解，冷却得浅棕色结晶，过滤，用甲醇洗涤得粗品。粗品经水重结晶、灭菌干燥即为成品。

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双甘肽海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

双甘肽文献

Abiogenic Syntheses of Lipoamino Acids and Lipopeptides and their Prebiotic Significance.

Orig. Life Evol. Biosph. 45 , 427-37, (2015)

Researchers have formed peptide bonds under a variety of presumed prebiotic conditions. Here it is proposed that these same conditions would have also formed amide bonds between fatty acids and amino ...

Recurrence of carbamoyl phosphate synthetase 1 (CPS1) deficiency in Turkish patients: characterization of a founder mutation by use of recombinant CPS1 from insect cells expression.

Mol. Genet. Metab. 113(4) , 267-73, (2014)

Carbamoyl phosphate synthetase 1 (CPS1) deficiency due to CPS1 mutations is a rare autosomal-recessive urea cycle disorder causing hyperammonemia that can lead to death or severe neurological impairme...

Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses.

Biochim. Biophys. Acta 1840(10) , 3073-8, (2014)

Tryptophan-histidine (Trp-His) was found to suppress the activity of the Ca²⁺/calmodulin (CaM)-dependent protein kinases II (CaMKII), which requires the Ca²⁺-CaM complex for an initial activation. In ...

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双甘肽