伊普吲哚

伊普吲哚用途

Iprindole 具有抗抑郁的生物活性,是一种弱的去甲肾上腺素和5-HT 摄取的抑制剂。
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伊普吲哚名称

[ CAS 号 ]:
5560-72-5

[ 中文名 ]:
伊普吲哚

[ 英文名 ]:
Iprindole

[英文别名 ]:

伊普吲哚生物活性

[ 描述 ]:

Iprindole 具有抗抑郁的生物活性,是一种弱的去甲肾上腺素和5-HT 摄取的抑制剂。

[ 相关类别 ]:

研究领域 >> 代谢疾病
研究领域 >> 神经疾病
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
信号通路 >> 神经信号通路 >> 5-HT受体

[体内研究]

依哌利多对去甲肾上腺素和5-羟色胺摄取的抑制作用小于50%,剂量为100 mg/kg。。

[参考文献]

[1]. M I Gluckman, et al. The pharmacology of iprindole, a new antidepressant. Psychopharmacologia. 1969;15(3):169-85.

伊普吲哚物理化学性质

[ 密度 ]:
1.04g/cm3

[ 沸点 ]:
435.4ºC at 760mmHg

[ 分子式 ]:
C19H28N2

[ 分子量 ]:
284.43900

[ 闪点 ]:
217.1ºC

[ 精确质量 ]:
284.22500

[ PSA ]:
8.17000

[ LogP ]:
4.25200

[ 外观性状 ]:
油状物

[ 折射率 ]:
1.573

[ 储存条件 ]:
2-8°C，密封，干燥

伊普吲哚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GY0350000
CHEMICAL NAME :
5H-Cyclooct(b)indole, 5-(3-(dimethylamino)propyl)-6,7,8,9,10,11-hexahydro-
CAS REGISTRY NUMBER :
5560-72-5
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H28-N2
MOLECULAR WEIGHT :
284.49
WISWESSER LINE NOTATION :
T B658 HN&&TJ H3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
484 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01206
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