二甲茚定
二甲茚定用途
二甲亚砜是一种有效的选择性组胺H1拮抗剂。二甲基亚砜损害皮肤伤口愈合(WH)。二甲基亚砜可以阻断K+电流[1][2]。
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二甲茚定名称
[ CAS 号 ]:
5636-83-9
[ 中文名 ]:
二甲茚定
[ 英文名 ]:
dimethindene
[中文别名 ]:
[英文别名 ]:
- Triten
- Dimethpyrindene
- Dimetindeno
- Dimetindene
- Pecofenil
- dimethindene
- Dimetindenum
- Foristal
- Fenistil
- Forhistal
二甲茚定生物活性
[ 描述 ]:
二甲亚砜是一种有效的选择性组胺H1拮抗剂。二甲基亚砜损害皮肤伤口愈合(WH)。二甲基亚砜可以阻断K+电流[1][2]。
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[体外研究]
二甲基亚砜(5-500μM；卵泡封闭的爪蟾卵母细胞)降低克罗马卡林诱导的K+电流,IC50值为29.5μM[2]。
[体内研究]
二甲基亚砜(0.25 mg；i.p.；一次；C57BL/6小鼠皮肤WH)损害皮肤伤口愈合(WH)并延迟皮肤伤口闭合[1]。动物模型：C57BL/6小鼠,皮肤WH[1]剂量：0.25 mg给药：腹腔注射；结果：与载体处理的小鼠相比,皮肤伤口延迟闭合。
二甲茚定物理化学性质
[ 密度 ]:
1.065 g/cm3
[ 沸点 ]:
416.3ºC at 760 mmHg
[ 熔点 ]:
50 - 53 °C
[ 分子式 ]:
C20H24N2
[ 分子量 ]:
292.41800
[ 闪点 ]:
205.6ºC
[ 精确质量 ]:
292.19400
[ PSA ]:
16.13000
[ LogP ]:
4.14670
[ 折射率 ]:
1.587
[ 储存条件 ]:
2-8°C
二甲茚定毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT0800000
- CHEMICAL NAME :
- Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-
- CAS REGISTRY NUMBER :
- 5636-83-9
- BEILSTEIN REFERENCE NO. :
- 0489974
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H24-N2
- MOLECULAR WEIGHT :
- 292.46
- WISWESSER LINE NOTATION :
- L56 BHJ C2N1&1 DY1&- BT6NJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 618 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 888 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
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