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棕榈酸

棕榈酸用途

Palmitic acid是一种常见于动物和植物中的长链饱和脂肪酸。

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棕榈酸名称

[ CAS 号 ]:
57-10-3

[ 中文名 ]:
棕榈酸

[ 英文名 ]:
Palmitic acid

[中文别名 ]:

[英文别名 ]:

n-hexadecanoic acid
1-hexadecanoic acid
hexdecanoic acid
Hexadecanoic acid
MFCD00002747
EINECS 200-312-9
Neo-Fat 16
Palmitic acid

棕榈酸生物活性

[ 描述 ]:

Palmitic acid是一种常见于动物和植物中的长链饱和脂肪酸。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

[相关活性小分子]

棕榈酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
340.6±5.0 °C at 760 mmHg

[ 熔点 ]:
61-62.5 °C(lit.)

[ 分子式 ]:
C₁₆H₃₂O₂

[ 分子量 ]:
256.424

[ 闪点 ]:
154.1±12.5 °C

[ 精确质量 ]:
256.240234

[ PSA ]:
37.30000

[ LogP ]:
7.15

[ 外观性状 ]:
白色芯片,晶体或粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.454

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.

[ 水溶解性 ]:
insoluble

棕榈酸MSDS

棕榈酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT4550000

CHEMICAL NAME :: Palmitic acid

CAS REGISTRY NUMBER :: 57-10-3

BEILSTEIN REFERENCE NO. :: 0607489

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C16-H32-O2

MOLECULAR WEIGHT :: 256.48

WISWESSER LINE NOTATION :: QV15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 37,251,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,105,1966 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81460 No. of Facilities: 1477 (estimated) No. of Industries: 23 No. of Occupations: 34 No. of Employees: 20670 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81460 No. of Facilities: 5543 (estimated) No. of Industries: 55 No. of Occupations: 61 No. of Employees: 105420 (estimated) No. of Female Employees: 20470 (estimated)

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棕榈酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
RT4550000

[ 海关编码 ]:
2915709000

棕榈酸合成路线

棕榈酸上下游产品

棕榈酸上游产品

棕榈酸下游产品

棕榈酸制备

1.自然界中广泛存在，几乎所有的油脂中都有含量不等的软脂酸组分。我国特产的乌桕油中，软脂酸的含量可高达60%以上，而棕榈树果实的棕榈油中含量大约为40%，但菜油中的含量则不足2%。将乌桕油或棕榈油水解、分馏、压榨分离不饱和脂肪酸后，经重结晶即制得棕榈酸。市售品棕榈酸一般熔点为57.5-62.5℃。

2.用板油或棕榈油经水解、酸化，分离不饱和脂肪酸后得棕榈酸，然后经重结晶可得纯棕榈酸。

3.将米糠油、椰子油、棕榈仁油等的混合脂肪酸经真空分馏而制得。

4. 烟草：OR，44；FC，9， 15， 18， 41， 43， 50；OR，18， 26；BU，9， 18， 26。

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棕榈酸海关

[ 海关编码 ]: 2915709000

[ 中文概述 ]:
2915709000. 棕榈酸及其盐和酯、硬脂酸盐、酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 硬脂酸和软脂酸的含量

[ Summary ]:
2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

棕榈酸文献

Kinetics and utilization of lipid sources during acute exercise and acipimox.

Am. J. Physiol. Endocrinol. Metab. 307(2) , E199-208, (2014)

Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics a...

Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells.

J. Virol. 88(16) , 9233-44, (2014)

Diacylglycerol acyltransferase-1 (DGAT1) is involved in the assembly of hepatitis C virus (HCV) by facilitating the trafficking of the HCV core protein to the lipid droplet. Here, we abrogated DGAT1 e...

The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.

PLoS Genet. 11(3) , e1005027, (2015)

Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that com...

更多文献

棕榈酸

棕榈酸用途

棕榈酸名称

棕榈酸生物活性

棕榈酸物理化学性质

棕榈酸MSDS

详细MSDS(安全技术说明书)

棕榈酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

棕榈酸安全信息

棕榈酸合成路线

详细合成路线

棕榈酸上下游产品

棕榈酸上游产品

棕榈酸下游产品

棕榈酸制备

棕榈酸海关

棕榈酸文献

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