4-羟基甲苯磺丁脲

4-羟基甲苯磺丁脲用途

4-Hydroxytolbutamide (Hydroxytolbutamide) 是 Tolbutamide 的代谢产物。4-Hydroxytolbutamide 被在体内 CYP2C8 和 CYP2C9 代谢。Tolbutamide 是第一代钾通道阻滞剂,是一种磺酰脲类口服降糖药。

点击显示

4-羟基甲苯磺丁脲名称

[ CAS 号 ]:
5719-85-7

[ 中文名 ]:
4-羟基甲苯磺丁脲

[ 英文名 ]:
4 hydroxy tolbutamide

[中文别名 ]:

[英文别名 ]:

1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea
hydroxymethyl-TB
4-OH-tolbutamide
Methylhydroxytolbutamide
hydroxymethyltolbutamide
Hydroxytolbutamide
4-Hydroxytolbutamide
4 hydroxy tolbutamide
[14C]-Hydroxytolbutamide
1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea

4-羟基甲苯磺丁脲生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 自噬 >> 自噬

研究领域 >> 代谢疾病

信号通路 >> 跨膜转运 >> 钾通道

[ 靶点 ]

Potassium channel

[参考文献]

[1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71.

[2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

4-羟基甲苯磺丁脲物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
100-102ºC

[ 分子式 ]:
C₁₂H₁₈N₂O₄S

[ 分子量 ]:
286.347

[ 闪点 ]:
2℃

[ 精确质量 ]:
286.098724

[ PSA ]:
103.88000

[ LogP ]:
0.70

[ 外观性状 ]:
白色至灰白色

[ 折射率 ]:
1.553

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: 12 mg/mL

4-羟基甲苯磺丁脲MSDS

4-羟基甲苯磺丁脲安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,Xn

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
16-36/37-24/25

[ 危险品运输编码 ]:
UN 1648 3 / PGII

[ WGK德国 ]:
3

[ 海关编码 ]:
29350090

4-羟基甲苯磺丁脲合成路线

4-羟基甲苯磺丁脲上下游产品

4-羟基甲苯磺丁脲上游产品

4-羟基甲苯磺丁脲下游产品

4-羟基甲苯磺丁脲文献

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

J. Pharm. Pharmacol. 66(9) , 1339-46, (2014)

The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-...

Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.

Food Chem. Toxicol. 76 , 94-102, (2015)

meso-Dihydroguaiaretic acid (MDGA) is a major component of Myristica fragrans and Machilus thunbergii that is traditionally used as a spice and for medicinal purposes. Despite reports of various biolo...

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food Chem. Toxicol. 68 , 117-27, (2014)

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...

更多文献