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刚果红

刚果红用途

Congo red 是一种偶氮染料。Congo red 结合已被广泛用于组织切片中淀粉样蛋白的测定。
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刚果红名称

[ CAS 号 ]:
573-58-0

[ 中文名 ]:
刚果红

[ 英文名 ]:
Congo Red

[中文别名 ]:

[英文别名 ]:

刚果红生物活性

[ 描述 ]:

Congo red 是一种偶氮染料。Congo red 结合已被广泛用于组织切片中淀粉样蛋白的测定。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
染料试剂
研究领域 >> 其他

[体外研究]

刚果红组织化学染色可作为一种简单的筛选工具,用于研究突变细胞中的聚集体是否具有错误折叠的β-折叠片状二级结构。刚果红组织化学染料具有与交叉的β-褶皱片结构特异性结合的能力。野生型HSPB1应通过以非天然构象结合蛋白质来维持蛋白质稳态,从而防止底物聚集。然而,T139M突变体在该功能中失败并导致错误折叠的蛋白质的累积,其被刚果红靶向以插入β-折叠的片状结构之间。刚果红组织化学染色可以作为一个简单的工具,以研究突变细胞中的聚集体是否具有错误折叠的β-折叠片二级结构[1]。

[细胞实验]

由于其大的细胞质体积，选择HeLa细胞用于这些研究。用突变体或野生型HSPB1构建体转染的细胞在盖玻片上生长24小时，然后用刚果红染色以确定聚集体是否显示淀粉样蛋白形成特性。简而言之，首先用10％福尔马林固定细胞10分钟，并用1％刚果红染色5分钟，然后用0.01％氢氧化钾在50％乙醇中脱色。然后将盖玻片通过分级乙醇浓度进行脱水并安装在封固剂中，并在罗丹明过滤器下通过荧光显微镜检查[1]。

[参考文献]

[1]. Amornvit J, et al. A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family. Brain Behav. 2017 Jul 21;7(8):e00774.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

刚果红物理化学性质

[ 密度 ]:
0.995 g/mL at 25 °C

[ 熔点 ]:
>360 °C(lit.)

[ 分子式 ]:
C32H22N6Na2O6S2

[ 分子量 ]:
696.663

[ 精确质量 ]:
696.083740

[ PSA ]:
232.64000

[ LogP ]:
10.78740

[ 外观性状 ]:
棕色-红色粉末

[ 储存条件 ]:
Flammables area

[ 水溶解性 ]:
soluble

刚果红MSDS

详细MSDS(安全技术说明书)

刚果红毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QK1400000
CHEMICAL NAME :
1-Naphthalenesulfonic acid, 3,3'-(4,4'-biphenylenebis(azo))bis(4-amino-, disodium salt
CAS REGISTRY NUMBER :
573-58-0
LAST UPDATED :
199710
DATA ITEMS CITED :
38
MOLECULAR FORMULA :
C32-H24-N6-O6-S2.2Na
MOLECULAR WEIGHT :
698.72
WISWESSER LINE NOTATION :
L66J BZ ESWQ CNUNR DR DNUN- CL66J BZ ESWQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
143 mg/kg
TOXIC EFFECTS :
Vascular - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1429 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Blood - change in clotting factors
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 gm/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - change in clotting factors
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - change in clotting factors
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - change in clotting factors
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - change in clotting factors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
140 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
140 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - germ cell effects (in offspring) Reproductive - Effects on Newborn - delayed effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 ug/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
300 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1500 mg/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
TYPE OF TEST :
DNA adduct

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - hamster Liver
DOSE/DURATION :
10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3158 No. of Facilities: 384 (estimated) No. of Industries: 8 No. of Occupations: 8 No. of Employees: 1523 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3158 No. of Facilities: 284 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 4271 (estimated) No. of Female Employees: 3442 (estimated)
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刚果红安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350-H361d

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R45;R63

[ 安全声明 (欧洲) ]:
S53-S45-S37/39-S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
QK1400000

[ 危险类别 ]:
6.1

刚果红上下游产品

刚果红上游产品

刚果红下游产品

刚果红制备

1.由联欢苯胺重氮化后，与1，4-氨基萘磺酸钠进行偶合，而后经盐析；过滤及干燥而制得。具体操作为：取48.4g联苯胺溶于300ml盐酸（含浓盐酸20ml）中，加冰冷至5℃以下，加30ml浓盐酸后，加入由14.4g亚硝酸钠配成的10%的水溶液。重氮化结束后，将重氮盐溶液慢慢加入150g对氨基萘磺酸钠和少量水配成的溶液中，放置半小时后，在充分搅拌下慢慢加入35g碳酸钠，使溶液呈碱性，加热至约80℃后，冷却，过滤，用饱和盐水洗涤，干燥即得成品。

工业制备原料消耗（kg/t）联苯胺（100%） 200 氨基萘磺酸钠（100%） 520 亚硝酸钠（工业） 160 盐酸（31%） 330 纯碱（工业） 340 精盐 2500 太古油 9 乙醇 60 乙酸钠 35 元明粉 50

2.将联苯胺溶于适量盐酸中，加热至80～90℃，使联苯胺完全溶解，将溶液冷至0～5℃，再加入相同量的盐酸。然后维持温度在5℃以下，搅拌下滴加10%的亚硝酸钠水溶液进行反应：

然后在充分搅拌下加入碳酸钠至溶液呈碱性，加热至80℃后冷却结晶，过滤，结晶用饱和盐水洗涤，干燥即可。
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刚果红文献

SUMO1 promotes Aβ production via the modulation of autophagy.

Autophagy 11(1) , 100-12, (2015)

Autophagy is one of the main mechanisms in the pathophysiology of neurodegenerative disease. The accumulation of autophagic vacuoles (AVs) in affected neurons is responsible for amyloid-β (Aβ) product...

Swift adsorptive removal of Congo red from aqueous solution by K1.33Mn8O16 nanowires.

J. Nanosci. Nanotechnol. 13(8) , 5452-60, (2013)

A swift and efficient approach to converting organic dye effluents into fresh water could be of substantial benefit. In this study, we presented facile hydrothermal synthesis of K1.33Mn8O16 nanowires ...

Phosphorylation-independent regulation of the diguanylate cyclase WspR.

PLoS Biol. 6 , e67, (2008)

Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second m...


更多文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：刚果红

公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：刚果红

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥128.0/100g ￥448.0/500g

联系人：刘佳

产品详情：刚果红

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Congo red

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥709.0/500mg ￥781.0/1g ￥1069.0/1g ￥需询单/1g

联系人：李先生

产品详情：Congo Red

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刚果红供应商

相关化合物

【刚果红】化源网提供刚果红CAS号573-58-0，刚果红MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询刚果红上化源网，专业又轻松。>>电脑版：刚果红

标题：刚果红_MSDS_用途_密度_刚果红CAS号【573-58-0】_化源网 地址：https://m.chemsrc.com/mip/cas/573-58-0_1191403.html