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3,3'-二硫代二丙酸二(N-羟基丁二酰亚胺)酯[交联剂]

用途

DSP Crosslinker 是一种可降解 (cleavable) 的 ADC linker,用于合成可用于合成抗体偶联药物 (ADC)。

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名称

[ CAS 号 ]:
57757-57-0

[ 中文名 ]:
3,3'-二硫代二丙酸二(N-羟基丁二酰亚胺酯)

[ 英文名 ]:
DSP Crosslinker

[中文别名 ]:

[英文别名 ]:

DSP
MFCD00042045
Di(N-succinimidyl) 3,3'-dithiodipropionate
dithiobis(succinimidyl propionate)
EINECS 260-931-5

生物活性

[ 描述 ]:

DSP Crosslinker 是一种可降解 (cleavable) 的 ADC linker,用于合成可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

研究领域 >> 炎症/免疫

[ 靶点 ]

Cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接物连接ADC细胞毒素。

[参考文献]

[1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717.

物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
560.1±60.0 °C at 760 mmHg

[ 熔点 ]:
128-133 °C

[ 分子式 ]:
C₁₄H₁₆N₂O₈S₂

[ 分子量 ]:
404.415

[ 闪点 ]:
292.6±32.9 °C

[ 精确质量 ]:
404.034790

[ PSA ]:
177.96000

[ LogP ]:
-1.66

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: 50 mg/mL

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2930909090

上下游产品

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海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

文献

Electrochemical Impedance Immunosensor Based on Self-Assembled Monolayers for Rapid Detection of Escherichia coli O157:H7 with Signal Amplification Using Lectin.

Sensors (Basel.) 15 , 19212-24, (2015)

Escherichia coli O157:H7 is a predominant foodborne pathogen with severe pathogenicity, leading to increasing attention given to rapid and sensitive detection. Herein, we propose an impedance biosenso...

Targeting delivery of tocopherol and doxorubicin grafted-chitosan polymeric micelles for cancer therapy: In vitro and in vivo evaluation.

Colloids Surf. B Biointerfaces 133 , 254-62, (2015)

In this study, we report the development of a novel, redox-sensitive chitosan-based targeted drug delivery system, containing two drugs. We determined whether the synthesized polymeric micelles (HPTOC...

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

Sci. Signal. 7(354) , rs7, (2014)

E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extra...

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