< 生产厂家价格 >

西奈芬净

西奈芬净用途

Sinefungin 是病毒mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。Sinefungin 是一种SET7/9 抑制剂,通过抑制 H3K4 甲基化来改善肾纤维化。

点击显示

西奈芬净名称

[ CAS 号 ]:
58944-73-3

[ 中文名 ]:
西奈芬净

[ 英文名 ]:
Sinefungin

[英文别名 ]:

Sinefungin
Antibiotic 32232RP
UNII:W2U467CIIL

西奈芬净生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶

研究领域 >> 炎症/免疫

[参考文献]

[1]. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

[2]. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.

西奈芬净物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
783.2±70.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₂₃N₇O₅

[ 分子量 ]:
381.39

[ 闪点 ]:
427.5±35.7 °C

[ 精确质量 ]:
381.176056

[ PSA ]:
208.65000

[ LogP ]:
-1.33

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.832

[ 储存条件 ]:
-20°C，密闭，干燥

西奈芬净毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HE3140000

CHEMICAL NAME :: D-glycero-alpha-L-talo-Decofuranuronic acid, 6,9-diamino-1-(6-amino-9H-purin-9-yl)- 1,5,6,7,8,9-hexadeoxy-

CAS REGISTRY NUMBER :: 58944-73-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H23-N7-O5

MOLECULAR WEIGHT :: 381.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,298,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 26,463,1973

点击显示

西奈芬净安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
HE3140000

西奈芬净合成路线

详细合成路线

西奈芬净上下游产品

西奈芬净上游产品

西奈芬净下游产品

西奈芬净文献

Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.

Br. J. Pharmacol. 172(3) , 857-68, (2015)

AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB...

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

Mol. Cancer Ther. 8 , 1579-1588, (2009)

DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore imp...

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

FEBS J. 277(9) , 2096-108, (2010)

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethyla...

更多文献