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2-苯并噁唑酮

2-苯并噁唑酮用途

2-Benzoxazolinone是抗利什曼原虫试剂,抗L. donovani的LC50为40 μg/mL[1]。它的衍生物具有抗微生物活性,可针对一系列的革兰氏阳性和阴性细菌[3]。衍生物具有抗群体感应功能[4]。

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2-苯并噁唑酮名称

[ CAS 号 ]:
59-49-4

[ 中文名 ]:
2-苯并唑啉酮

[ 英文名 ]:
2-Benzoxazolinone

[中文别名 ]:

[英文别名 ]:

1,3-Benzoxazol-2(3H)-one
Benzoxazolinone
MFCD00005716
2-Benzoxaxolol
Benzoxazole-2-ol
2-Benzoxazolol
BENZOXAZOLONE
3H-benzoxazol-2-one
2(3H)-Benzoxazolone
2-BENZOXAZOLONE

2-苯并噁唑酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

天然产物 >> 生物碱

研究领域 >> 感染

[ 靶点 ]

LC50: 40 μg/mL (L. donovani)[1]

[体外研究]

2-苯并恶唑啉酮(0.1-5 mM)通过产生ROS和各种清除酶活性的上调诱导绿豆中的氧化应激[2]。

[参考文献]

[1]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8.

[2]. Batish DR, et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus). Plant Physiology and Biochemistry 44(11-12):819-27

[3]. Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70(2):245-53.

[4]. Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62(7):330-4.

[相关活性小分子]

2-苯并噁唑酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
299ºC at 760 mmHg

[ 熔点 ]:
137-139 °C(lit.)

[ 分子式 ]:
C₇H₅NO₂

[ 分子量 ]:
135.120

[ 闪点 ]:
160 °C

[ 精确质量 ]:
135.032028

[ PSA ]:
46.00000

[ LogP ]:
1.16

[ 外观性状 ]:
略米色粉末

[ 折射率 ]:
1.586

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
soluble in hot water

2-苯并噁唑酮MSDS

详细MSDS(安全技术说明书)

2-苯并噁唑酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM4905000

CHEMICAL NAME :: 2-Benzoxazolinone

CAS REGISTRY NUMBER :: 59-49-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H5-N-O2

MOLECULAR WEIGHT :: 135.13

WISWESSER LINE NOTATION :: T56 BMVOJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),341,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 554 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(8),36,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3892 mg/m3

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(8),36,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

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2-苯并噁唑酮安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36-S24/25

[ WGK德国 ]:
3

[ RTECS号 ]:
DM4905000

[ 海关编码 ]:
2934999090

2-苯并噁唑酮合成路线

详细合成路线

2-苯并噁唑酮上下游产品

2-苯并噁唑酮上游产品

2-苯并噁唑酮下游产品

2-苯并噁唑酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%