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2-氨基-6-甲基庚烷盐酸盐

2-氨基-6-甲基庚烷盐酸盐用途

2-Amino-6-methylheptane hydrochloride是局部麻醉剂和血管收缩剂,但主要作为octamylamine的药物中间体。

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2-氨基-6-甲基庚烷盐酸盐名称

[ CAS 号 ]:
5984-59-8

[ 中文名 ]:
(1,5-二甲基己基)氯化铵

[ 英文名 ]:
2-Amino-6-methylheptane hydrochloride

[中文别名 ]:

2-氨基-6-甲基庚烷盐酸盐

[英文别名 ]:

(1,5-dimethylhexyl)ammonium chloride
2-Amino-6-methylheptane hydrochloride

2-氨基-6-甲基庚烷盐酸盐生物活性

[ 描述 ]:

2-Amino-6-methylheptane hydrochloride是局部麻醉剂和血管收缩剂,但主要作为octamylamine的药物中间体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

通过将盐酸盐或游离碱2-氨基-6-甲基庚烷的溶液热带应用于兔眼来产生局部麻醉。在用戊巴比妥钠麻醉的狗中静脉注射,2-氨基-6-甲基庚烷盐酸盐显示1/500-1/1000肾上腺素的升压活性。发现2-氨基-6-甲基庚烷盐酸盐导致心率和收缩幅度增加。在用戊巴比妥钠麻醉的狗中静脉注射,每千克体重2-氨基-6-甲基庚烷盐酸盐0.5至1.0毫克的剂量对小肠,膀胱逼尿肌,尿液分泌或呼吸没有可检测的影响。在大鼠腹膜内,发现2-氨基-6-甲基庚烷盐酸盐在无毒剂量下几乎完全没有中枢神经系统刺激作用。在每天吸入2-氨基-6-甲基庚烷游离碱10天和30天的兔或大鼠中,没有发现气管-支气管树粘膜刺激的组织学证据[1]。

[参考文献]

[1]. Fellows EJ, et al. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther. 1947 Aug;90(4):351-8.

[相关活性小分子]

2-氨基-6-甲基庚烷盐酸盐物理化学性质

[ 沸点 ]:
155ºC at 760 mmHg

[ 熔点 ]:
139-140 ºC

[ 分子式 ]:
C₈H₂₀ClN

[ 分子量 ]:
165.70400

[ 闪点 ]:
48.9ºC

[ 精确质量 ]:
165.12800

[ PSA ]:
26.02000

[ LogP ]:
3.66220

[ 储存条件 ]:
-20°C，密闭，干燥

2-氨基-6-甲基庚烷盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MQ5075000

CHEMICAL NAME :: Hexylamine, 1,5-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 5984-59-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H19-N.Cl-H

MOLECULAR WEIGHT :: 165.74

WISWESSER LINE NOTATION :: 1Y1&3YZ1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947