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盐酸奥布卡因

盐酸奥布卡因用途

Oxybuprocaine hydrochloride (Benoxinate hydrochloride) 可逆地阻断钠通道 (sodium channels),并防止角膜,结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科和耳鼻喉科。
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盐酸奥布卡因名称

[ CAS 号 ]:
5987-82-6

[ 中文名 ]:
奥布卡因盐酸盐

[ 英文名 ]:
benoxinate hydrochloride

[中文别名 ]:

[英文别名 ]:

盐酸奥布卡因生物活性

[ 描述 ]:

Oxybuprocaine hydrochloride (Benoxinate hydrochloride) 可逆地阻断钠通道 (sodium channels),并防止角膜,结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科和耳鼻喉科。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道
研究领域 >> 神经疾病

[体内研究]

盐酸氧丁普鲁卡因(盐酸苯诺辛酯；27.6,51.7,103.5,413.9μg；s.c.)对大鼠针刺有剂量依赖性阻滞作用[1]。盐酸氧丁普鲁卡因(27.6μg)可产生100%的感觉/伤害性阻滞[1]。动物模型：雄性Sprague-Dawley大鼠(203-253 g)[1]剂量：27.6、51.7、103.5、413.9μg给药：SC结果：对针刺提供剂量依赖性阻滞。

[参考文献]

[1]. Chen YW, et al. The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):601-6.

[2]. Chen YW, et al. Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. Anesth Analg. 2018 May;126(5):1721-1728.

[3]. Page M, et al. Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topicalocular anesthetic for use in ophthalmic procedures. Clin Ophthalmol. 2009;3:601-9. Epub 2009 Nov 2.

盐酸奥布卡因物理化学性质

[ 沸点 ]:
446.9ºC at 760 mmHg

[ 熔点 ]:
158 - 162ºC

[ 分子式 ]:
C17H29ClN2O3

[ 分子量 ]:
344.877

[ 闪点 ]:
224.1ºC

[ 精确质量 ]:
344.186676

[ PSA ]:
64.79000

[ LogP ]:
4.32950

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
室温

盐酸奥布卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG1502900
CHEMICAL NAME :
Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, monohydrochloride
CAS REGISTRY NUMBER :
5987-82-6
LAST UPDATED :
199509
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H28-N2-O3.Cl-H
MOLECULAR WEIGHT :
344.93
WISWESSER LINE NOTATION :
4OR BZ EVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1957,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
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盐酸奥布卡因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S26-S36

[ 危险品运输编码 ]:
UN 1544PSN2 6.1 / PGIII

[ RTECS号 ]:
DG15029

[ 海关编码 ]:
29225000

盐酸奥布卡因制备

【方法一】
将3-氧-4-硝基苯甲酸与乙醇酯化得到的乙酯，与丁基溴反应，获得丁氧基硝基苯甲酸乙酯，加苛性碱皂化，生成3-丁氧基-4-硝基苯甲酸。然后，将其与亚硫酰氯反应得到酰基氯中间体，再与二乙氨基乙醇酯化，得到3-丁氧基-4-硝基苯甲酸二乙氨基乙酯，经还原成盐即制成盐酸丁氧普鲁卡因。
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盐酸奥布卡因海关

[ 海关编码 ]: 29225000

盐酸奥布卡因文献

Postoperative changes in amniotic membrane as a carrier for allogeneic cultured limbal epithelial transplantation.

Am. J. Ophthalmol. 158(6) , 1192-1198.e1, (2014)

To investigate the morphologic changes and outcomes of the amniotic membrane as a carrier for allogeneic cultivated limbal epithelial transplantation.Prospective, noncomparative, interventional study....

The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs.

PLoS ONE 9(5) , e96952, (2014)

To investigate whether the Sonic hedgehog (Shh) signaling induces myopic development by increasing the expression of matrix metalloproteinase (MMP)-2 in guinea pigs.A translucent diffuser was glued on...

Corneal thickness differences between sexes after oxybuprocaine eye drops.

Optom. Vis. Sci. 92(1) , 89-94, (2015)

We aimed to analyze the corneal thickness (CT) values of female and male subjects before and after instillation of oxybuprocaine 0.4% anesthetic eye drops.The CT of 30 female subjects and 28 male subj...


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产品详情：奥布卡因盐酸盐

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￥589.0/1g ￥669.0/50mg ￥需询单/1g ￥需询单/1g

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产品详情：Oxybuprocaine HCl

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￥3913.9/100g ￥146.9/1g ￥1484.9/25g ￥451.9/5g

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产品详情：奥布卡因 盐酸盐

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