盐酸布比卡因

盐酸布比卡因用途

Bupivacaine hydrochloride monohydrate 是一种 NMDA 受体抑制剂。Bupivacaine hydrochloride monohydrate 可以阻断钠、L-钙和钾通道。Bupivacaine hydrochloride monohydrate 有效阻断 SCN5A 通道,IC50 为 69.5 μM。Bupivacaine hydrochloride monohydrate 可用于慢性疼痛的研究。

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盐酸布比卡因名称

[ CAS 号 ]:
73360-54-0

[ 中文名 ]:
盐酸布比卡因

[ 英文名 ]:
Bupivacaine Hydrochloride

[英文别名 ]:

Win 11,318
Bupivacaine HCl H2-O
Bupivacaine hydrochloride
Marcaine (TN)

盐酸布比卡因生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

信号通路 >> 跨膜转运 >> 钠通道

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 癌症

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

NMDA Receptor

[参考文献]

[1]. Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42.

[2]. Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34.

[3]. Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na⁺ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.

盐酸布比卡因物理化学性质

[ 熔点 ]:
255-259℃

[ 分子式 ]:
C₁₈H₃₁ClN₂O₂

[ 分子量 ]:
342.90

[ 精确质量 ]:
342.20700

[ PSA ]:
45.06000

[ LogP ]:
5.22160

盐酸布比卡因MSDS

详细MSDS(安全技术说明书)

盐酸布比卡因安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGII

[ RTECS号 ]:
TK6125000

[ 危险类别 ]:
6.1

盐酸布比卡因文献

Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cells.

J. Immunol. 193(11) , 5525-33, (2014)

The developmental pathways of regulatory T cells (T(reg)) generation in the thymus are not fully understood. In this study, we reconstituted thymic development of Zap70-deficient thymocytes with a tet...

The distinct effects of lipid emulsions used for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel Nav1.5.

Anesth. Analg. 117(5) , 1101-8, (2013)

Systemic administration of lipid emulsions is an established treatment for local anesthetic intoxication. However, it is unclear by which mechanisms lipids achieve this function. The high cardiac toxi...

MK-801-induced behavioural sensitisation alters dopamine release and turnover in rat prefrontal cortex.

Psychopharmacol. Ser. 232(3) , 509-17, (2015)

Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be importan...

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