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(+)-盐酸布比卡因

(+)-盐酸布比卡因用途

盐酸布卡宁是一种阿啡生物碱,是多巴胺受体抑制剂。盐酸布卡宁抑制多巴胺合成。盐酸布卡宁还具有类似神经抑制剂、抗惊厥和抗伤害的作用[1][2][3]。

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(+)-盐酸布比卡因名称

[ CAS 号 ]:
632-47-3

[ 中文名 ]:
紫堇碱盐酸盐

[ 英文名 ]:
BULBOCAPNINE HYDROCHLORIDE

[中文别名 ]:

载堇碱盐酸盐

[英文别名 ]:

N-METHYLLAUNOBINE HYDROCHLORIDE
MFCD00069363
EINECS 211-178-6
BULBOCAPNINE HCL
Buibocapnine hydrochloride

(+)-盐酸布比卡因生物活性

[ 描述 ]:

盐酸布卡宁是一种阿啡生物碱,是多巴胺受体抑制剂。盐酸布卡宁抑制多巴胺合成。盐酸布卡宁还具有类似神经抑制剂、抗惊厥和抗伤害的作用[1][2][3]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

研究领域 >> 炎症/免疫

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Shin JS, et al. Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells. Neurosci Lett. 1998 Mar 20;244(3):161-4.

[2]. Zetler G. Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81.

[3]. Kohli JD,et al. Bulbocapnine is not a selective DA1 receptor antagonist. J Pharm Pharmacol. 1986 May;38(5):401-2.

(+)-盐酸布比卡因物理化学性质

[ 沸点 ]:
504ºC at 760 mmHg

[ 熔点 ]:
209-210ºC

[ 分子式 ]:
C₁₉H₂₀ClNO₄

[ 分子量 ]:
361.82

[ 闪点 ]:
258.6ºC

[ 精确质量 ]:
361.10800

[ PSA ]:
51.16000

[ LogP ]:
3.62150

[ 外观性状 ]:
solid | tan

[ 储存条件 ]:
2-8°C

(+)-盐酸布比卡因MSDS

详细MSDS(安全技术说明书)

(+)-盐酸布比卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE1054000

CHEMICAL NAME :: 6a-alpha-Aporphin-11-ol, 10-methoxy-1,2-(methylenedioxy)-, hydrochloride

CAS REGISTRY NUMBER :: 632-47-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H19-N-O4.Cl-H

MOLECULAR WEIGHT :: 361.85

WISWESSER LINE NOTATION :: T D56 J666 1A T EO GO RN FH&&&TTJ KQ LO1 R1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 236,149,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,27,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,375,1962

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(+)-盐酸布比卡因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CE1054000