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肉豆蔻醚

肉豆蔻醚用途

Myristicine 是血清素受体拮抗剂,一种弱的单胺氧化酶 (MAO) 抑制剂。 Myristicine 是肉豆蔻精油的主要成分。Myristicine 滥用会产生致幻作用,器官损伤等。

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肉豆蔻醚名称

[ CAS 号 ]:
607-91-0

[ 中文名 ]:
肉豆蔻醚

[ 英文名 ]:
Myristicin

[中文别名 ]:

[英文别名 ]:

myristicine
4-methoxy-6-prop-2-en-1-yl-1,3-benzodioxole
6-Allyl-4-methoxy-1,3-benzodioxole
1,3-Benzodioxole, 4-methoxy-6-(2-propen-1-yl)-
MFCD00133549
Myristicin
4-Méthoxy-6-(2-propèn-1-yl)-1,3-benzodioxole
3-methoxy-4,5-methylenedioxyallylbenzene
1-allyl-4,5-methylenedioxy-3-methoxybenzene
EINECS 210-146-9

肉豆蔻醚生物活性

[ 描述 ]:

Myristicine 是血清素受体拮抗剂,一种弱的单胺氧化酶 (MAO) 抑制剂。 Myristicine 是肉豆蔻精油的主要成分。Myristicine 滥用会产生致幻作用,器官损伤等。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[参考文献]

[1]. Kalbhen DA, et al. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans).Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4.

[2]. Dawidowicz AL, et al. Simple and rapid determination of myristicin in human serum.Forensic Toxicol. 2013 Jan;31(1):119-123. Epub 2012 Aug 15.

肉豆蔻醚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
276.5±0.0 °C at 760 mmHg

[ 熔点 ]:
<-20ºC

[ 分子式 ]:
C₁₁H₁₂O₃

[ 分子量 ]:
192.211

[ 闪点 ]:
89.8±16.0 °C

[ 精确质量 ]:
192.078644

[ PSA ]:
27.69000

[ LogP ]:
3.26

[ 外观性状 ]:
oil | clear, light yellow

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

肉豆蔻醚MSDS

详细MSDS(安全技术说明书)

肉豆蔻醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY2625000

CHEMICAL NAME :: Benzene, 5-allyl-1-methoxy-2,3-(methylenedioxy)-

CAS REGISTRY NUMBER :: 607-91-0

BEILSTEIN REFERENCE NO. :: 0166218

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H12-O3

MOLECULAR WEIGHT :: 192.23

WISWESSER LINE NOTATION :: T56 BO DO CHJ FO1 H2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5700 ug/kg

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - euphoria Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Liver - fatty liver degeneration

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - other changes Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - other changes Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

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肉豆蔻醚安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361f-H412

[ 警示性声明 ]:
P201-P273-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R52/53

[ 安全声明 (欧洲) ]:
S61

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
CY2625000

[ 危险类别 ]:
9.0

[ 海关编码 ]:
2932999099

肉豆蔻醚上下游产品

肉豆蔻醚上游产品

肉豆蔻醚下游产品

肉豆蔻醚海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

肉豆蔻醚文献

Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.

Chem. Biol. Interact. 218 , 1-9, (2014)

Myristicin, an allylbenzene, is a major active component of various spices, such as nutmeg and cinnamon, plants from the Umbelliferae family or in some essential oils, such as oils of clove or marjora...

Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects.

J. Toxicol. Environ. Health. B. Crit. Rev. 15(6) , 365-95, (2012)

The methylenedioxyphenyl (MDP) substituent is a structural feature present in many plant chemicals that deter foraging by predatory insects and herbivores. With increasing use of herbal extracts in al...

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.

Nat. Prod. Commun. 8(9) , 1305-8, (2013)

We have hydrodistilled the essential oil (EO) from the aerial parts of the Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS and NMR analys...

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