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2-氯-6-(哌嗪-1-基)吡嗪盐酸盐

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐用途

MK-212(CPP)单盐酸盐是一种中枢作用的5-HT1C/5-HT2激动剂。MK-212单盐酸盐可以刺激大脑皮层的磷脂酰肌醇水解[1]。

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2-氯-6-(哌嗪-1-基)吡嗪盐酸盐名称

[ CAS 号 ]:
61655-58-1

[ 中文名 ]:
盐酸MK 212

[ 英文名 ]:
MK-212

[英文别名 ]:

6-chloro-2-(piperazinyl)pyrazine hydrochloride
1-(6-Chloro-2-pyrazinyl)piperazine hydrochloride
1-(6-chloropyrazin-2-yl)piperazine hydrochloride
Sodium chloride
6-chloro-2-(1-piperazinyl)-pyrazine hydrochloride
MK 212 hydrochloride
4-(2chloro-6-pyrazinyl)piperazine hydrochloride
MK-212

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐生物活性

[ 描述 ]:

MK-212(CPP)单盐酸盐是一种中枢作用的5-HT1C/5-HT2激动剂。MK-212单盐酸盐可以刺激大脑皮层的磷脂酰肌醇水解[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[ 靶点 ]

5-HT1C Receptor

5-HT2 Receptor

[参考文献]

[1]. Lee HS, et, al. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry. 1992 Mar 1;31(5):460-70.

[2]. Conn PJ, et, al. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7.

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐物理化学性质

[ 分子式 ]:
C₈H₁₂Cl₂N₄

[ 分子量 ]:
235.11400

[ 精确质量 ]:
234.04400

[ PSA ]:
41.05000

[ LogP ]:
1.73540

[ 外观性状 ]:
白色至类白色粉末

[ 储存条件 ]:
2-8°C，惰性气体

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
H301

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933990090

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐上下游产品

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐上游产品

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐下游产品

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氯-6-(哌嗪-1-基)吡嗪盐酸盐文献

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Serotonin (5-HT) is a critical neurotransmitter in the control of autonomic functions. 5-HT(3) receptors participate in vagal afferent feedback to decrease food intake and regulate cardiovascular refl...

Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

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5-HT(2C) receptor agonists have considerable therapeutic potential, however there is little in vivo data to compare the potency and selectivity of 5-HT(2C) receptor agonists. Since 5-HT(2C) receptor a...

Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

J. Neurophysiol. 96(5) , 2177-88, (2006)

The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs f...

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