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羟基香豆素

羟基香豆素用途

4-Hydroxymephenytoin 是抗癫痫药 mephenytoin 的代谢物; mephenytoin 为 CYP2C19 的一种配体。

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羟基香豆素名称

[ CAS 号 ]:
61837-65-8

[ 中文名 ]:
羟基香豆素

[ 英文名 ]:
(+/-)-4-Hydroxy Mephenytoin

[中文别名 ]:

[英文别名 ]:

4-hydroxy mephenytoin
4-Hydroxymephenytoin

羟基香豆素生物活性

[ 描述 ]:

4-Hydroxymephenytoin 是抗癫痫药 mephenytoin 的代谢物; mephenytoin 为 CYP2C19 的一种配体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[体外研究]

4-羟基甲苯喋呤是mephenytoin的一种新陈代谢,它是一种抗癫痫药物,用作CYP2C19底物[1]。 4-Hydroxymephenytoin(4'-Hydroxymephenytoin)用于开发UltraPerformance LC(UPLC)串联质谱分析,用于评估人尿液或血浆样品中的CYP探针药物及其相关代谢物[2]。

[参考文献]

[1]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94.

[2]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12.

[相关活性小分子]

羟基香豆素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
153-154ºC

[ 分子式 ]:
C₁₂H₁₄N₂O₃

[ 分子量 ]:
234.251

[ 精确质量 ]:
234.100449

[ PSA ]:
69.64000

[ LogP ]:
0.66

[ 折射率 ]:
1.568

[ 储存条件 ]:
2-8℃

羟基香豆素MSDS

详细MSDS(安全技术说明书)

羟基香豆素安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol

羟基香豆素文献

The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet.

Biochem. Pharmacol. 93(3) , 389-400, (2015)

There is an unmet medical need for novel NAFLD treatments. Here we have examined the effects of liver-selective NO donor (V-PYRRO/NO) as compared with metformin on hepatic steatosis and glucose tolera...

Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations.

Nanoscale Res. Lett. 9(1) , 642, (2014)

Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms ...

Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method.

Rapid Commun. Mass Spectrom. 18(15) , 1675-80, (2004)

A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method without the use of sample extraction was developed for the simultaneous quantification of urinary concentrat...

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