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罗丹明123

罗丹明123用途

Rhodamine 123 是一种荧光染料(λex=503 nm, λem=527 nm)。

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罗丹明123名称

[ CAS 号 ]:
62669-70-9

[ 中文名 ]:
罗丹明 123

[ 英文名 ]:
Rhodamine 123

[中文别名 ]:

罗丹明123

[英文别名 ]:

RHODAMINE METHYL ESTER CHLORIDE
rh123
MFCD00012664
RHODAMINE 123 HYDROCHLORIDE
Rhodamine 123
RHODAMINE 123,PURE
rhodamine 110 methyl ester
Rhodamine-123
EINECS 263-687-8

罗丹明123生物活性

[ 描述 ]:

Rhodamine 123 是一种荧光染料(λex=503 nm, λem=527 nm)。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

染料试剂

[体外研究]

R123荧光的强度在浓度为50μM时具有峰值,并且在较高浓度下由于自猝灭而降低至零[1]。

[激酶实验]

在室温下进行测量，使用配备有荧光阳离子R123作为探针的磁力搅拌器的分光光度计连续搅拌线粒体悬浮液。激发和发射波长分别为503nm和527nm。培养基是呼吸缓冲液。加入R123和丙酮酸钠至终浓度分别为50nM和10mM。在整个记录过程中，分离的线粒体保持稳定的膜电位（±5％）[1]。

[参考文献]

[1]. M. Huang, et al. Mitochondrial Inner Membrane Electrophysiology Assessed by Rhodamine-123 Transport and Fluorescence. Ann Biomed Eng. 2007 Jul; 35(7): 1276–1285.

[相关活性小分子]

罗丹明123物理化学性质

[ 熔点 ]:
235 °C

[ 分子式 ]:
C₂₁H₁₇ClN₂O₃

[ 分子量 ]:
380.824

[ 精确质量 ]:
380.092773

[ PSA ]:
89.31000

[ LogP ]:
5.53580

[ 外观性状 ]:
红色至棕色粉末

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Partially soluble

罗丹明123MSDS

详细MSDS(安全技术说明书)

罗丹明123毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE0883000

CHEMICAL NAME :: Xanthylium, 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)-, chloride

CAS REGISTRY NUMBER :: 62669-70-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H17-N2-O3.Cl

MOLECULAR WEIGHT :: 380.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 7-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 9,29,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 7-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 40,143,1989

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罗丹明123安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
ZE0883000

[ 海关编码 ]:
2932999099

罗丹明123上下游产品

罗丹明123上游产品

罗丹明123下游产品

罗丹明123海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

罗丹明123文献

Protective effect of carboxymethylated chitosan on hydrogen peroxide-induced apoptosis in nucleus pulposus cells.

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Although the etiology of intervertebral disc degeneration is poorly understood, one approach to prevent this process may be to inhibit apoptosis. In the current study, the anti‑apoptotic effects of ca...

Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion.

Mol. Med. Report. 11(2) , 1428-34, (2014)

Auranofin (Au), an inhibitor of thioredoxin reductase, is a known anti‑cancer drug. In the present study, the anti‑growth effect of Au on HeLa cervical cancer cells was examined in association with le...

TLR signaling modulates side effects of anticancer therapy in the small intestine.

J. Immunol. 194(4) , 1983-95, (2015)

Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology re...

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