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胆红素

胆红素用途

Bilirubin 是血红素分解代谢的黄色分解产物,是肝功能的重要指标。

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胆红素名称

[ CAS 号 ]:
635-65-4

[ 中文名 ]:
胆红素

[ 英文名 ]:
bilirubin

[中文别名 ]:

[英文别名 ]:

(4Z,15Z)-Bilirubin IXa
Biliyubin
filirubin
Cholerythrin
EINECS 211-239-7
(Z,Z)-Bilirubin
bilirubin
hemetoidin
(Z,Z)-Bilirubin IXa
Bilirubin IXa

胆红素生物活性

[ 描述 ]:

Bilirubin 是血红素分解代谢的黄色分解产物,是肝功能的重要指标。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 心血管疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

未缀合胆红素抑制ADAMTS13以浓度依赖性方式切割F485-rVWF73-H,D633-rVWF73-H和GST-rVWF71-11K,半数最大抑制浓度(IC50)为~13μM,~70μM ,和~17μM。未缀合的胆红素也在剂量依赖性地抑制ADAMTS13在变性条件下对多聚体VWF的切割[1]。胆红素在体外具有抗氧化和抗诱变作用[2]。

[参考文献]

[1]. Lu RN, et al. Unconjugated Bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J Thromb Haemost. 2015 Jun;13(6):1064-72.

[2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65.

[相关活性小分子]

胆红素物理化学性质

[ 密度 ]:
1.2163

[ 沸点 ]:
641.7°C

[ 熔点 ]:
192 °C

[ 分子式 ]:
C₃₃H₃₆N₄O₆

[ 分子量 ]:
584.662

[ 闪点 ]:
478.1±37.1 °C

[ 精确质量 ]:
584.263489

[ PSA ]:
164.38000

[ LogP ]:
3.15

[ 外观性状 ]:
淡橙色至棕色结晶粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Stable. Refrigerate.

[ 水溶解性 ]:
难溶

胆红素MSDS

胆红素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU3038000

CHEMICAL NAME :: Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19 -dioxo- 3,18-divinyl-

CAS REGISTRY NUMBER :: 635-65-4

BEILSTEIN REFERENCE NO. :: 0074376

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C33-H36-N4-O6

MOLECULAR WEIGHT :: 584.73

WISWESSER LINE NOTATION :: T5VMYTJ D1 E1U1 CU1- ET5MYTJ C2VQ D1 BU1- ET5MYTJ C1 D2VQ BU1- ET5MVTJ C1 D1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 175 mg/kg

SEX/DURATION :: female 9-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 127,497,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 25 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 127,497,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81726 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1390 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81726 No. of Facilities: 1176 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 12638 (estimated) No. of Female Employees: 9389 (estimated)

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胆红素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R62

[ 安全声明 (欧洲) ]:
22-24/25-36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DU3038000

[ 海关编码 ]:
29339990

胆红素合成路线

胆红素上下游产品

胆红素上游产品

胆红素下游产品

胆红素制备

1.将新鲜的猪胆汁，在搅拌下加入3～3.5倍量的澄清饱和石灰水中，搅拌均匀，pH值为11～12，加热至50℃时出现的泡沫用纱布撇去，继续加热至沸，保持2min，冷却，过滤，得钙盐。于钙盐中加入适量水，捣成糊状，过30～40目筛，加入1%的亚硫酸氢钠。然后在搅拌下缓缓滴加1∶1工业盐酸液，至pH=1～2，静置05h。用双层纱布沥去酸水，得泥状物。泥状物中加入适量95%的乙醇捣成稀糊状，再加入约20kg95%的乙醇和10g亚硫酸氢钠的水溶液，充分搅拌均匀。得到的乙醇液pH值在3.0～3.5之间，于约3℃静置沉淀18h。虹吸去除上层乙醇，于下层中加入45～50℃温水，静置分层，得富集胆红素的漂浮物（即浮于液面物），虹吸去除下层废水。于漂浮物中加入氯仿约30kg，回流提取2h。将提取液置分液器中分层，下层氯仿液过滤后，于常压下蒸发出氯仿。再于残余物中加入适量95%的乙醇，继续蒸发至馏出乙醇中不带氯仿味，过滤，用温乙醇和乙醚清洗，抽干，干燥，即得胆红素成品。

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胆红素海关

[ 海关编码 ]: 29339990

胆红素文献

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

Toxicol. Appl. Pharmacol. 282(1) , 77-89, (2015)

The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a ...

Stratification of risk of death in severe acute alcoholic hepatitis using a panel of adipokines and cytokines.

Alcohol. Clin. Exp. Res. 38(11) , 2712-21, (2014)

Dysregulated adipose tissue metabolism has been implicated in the pathogenesis of alcoholic liver disease in murine models. We aimed to characterize serum markers of adipose tissue metabolism and infl...

Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site.

Org. Biomol. Chem. 13(10) , 3040-7, (2015)

Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemi...

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胆红素

胆红素用途

胆红素名称

胆红素生物活性

胆红素物理化学性质

胆红素MSDS

详细MSDS(安全技术说明书)

胆红素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

胆红素安全信息

胆红素合成路线

详细合成路线

胆红素上下游产品

胆红素上游产品

胆红素下游产品

胆红素制备

胆红素海关

胆红素文献

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