交链孢酚

交链孢酚用途

Alternariol 是由 Alternaria 产生的一种霉菌毒素。Alternariol 可抑制拓扑异构酶 I 和 II 酶 (topoisomerase I, topoisomerase II) 的催化活性。Alternariol 具有多种治疗和生物学特性,如植物毒性,细胞毒性,抗 HIV,抗癌和抗微生物特性。

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交链孢酚名称

[ CAS 号 ]:
641-38-3

[ 中文名 ]:
交链孢酚

[ 英文名 ]:
Alternariol

[中文别名 ]:

交链孢

[英文别名 ]:

Alternariol
Alternariol from Alternaria sp.
3,7,9-Trihydroxy-1-methyl-6H-benzo[c]chromen-6-one
AOH
3,7,9-trihydroxy-1-methylbenzo[c]chromen-6-one

交链孢酚生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

研究领域 >> 感染

[参考文献]

[1]. Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352.

[2]. Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577.

交链孢酚物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
586.9±39.0 °C at 760 mmHg

[ 熔点 ]:
350°C (rough estimate)

[ 分子式 ]:
C₁₄H₁₀O₅

[ 分子量 ]:
258.226

[ 闪点 ]:
232.3±20.6 °C

[ 精确质量 ]:
258.052826

[ PSA ]:
90.90000

[ LogP ]:
2.93

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.731

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

交链孢酚MSDS

详细MSDS(安全技术说明书)

交链孢酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP8757000

CHEMICAL NAME :: 6H-Dibenzo(b,d)pyran-6-one, 1-methyl-3,7,9-trihydroxy-

CAS REGISTRY NUMBER :: 641-38-3

BEILSTEIN REFERENCE NO. :: 0244839

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H10-O5

MOLECULAR WEIGHT :: 258.24

WISWESSER LINE NOTATION :: T B666 HOVJ C1 EQ KQ MQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 9-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973

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交链孢酚安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
28-36/37/39-45

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
HP8757000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2914400090

交链孢酚上下游产品

交链孢酚上游产品

交链孢酚下游产品

交链孢酚海关

[ 海关编码 ]: 2914400090

[ 中文概述 ]:
2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

交链孢酚文献

Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Toxicology 326 , 119-29, (2014)

The mycotoxin alternariol (AOH), a frequent contaminant in fruit and grain, is known to induce cellular stress responses such as reactive oxygen production, DNA damage and cell cycle arrest. Cellular ...

AFLP variability, toxin production, and pathogenicity of Alternaria species from Argentinean tomato fruits and puree.

Int. J. Food Microbiol. 145(2-3) , 414-9, (2011)

Large amounts of tomato fruits and derived products are produced in Argentina and may be contaminated by Alternaria toxins. Limited information is available on the genetic variability, toxigenicity, a...

Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice.

Toxicol. Lett. 214(1) , 46-52, (2012)

Alternaria spp. are known to form a spectrum of secondary metabolites with alternariol (AOH), alternariol monomethyl ether (AME), altenuene (ALT) and tenuazonic acid (TA) as the major mycotoxins with ...

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