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屈螺酮

屈螺酮用途

Drospirenone(Dihydrospirorenone)是合成的孕酮,是spironolactone的类似物。

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屈螺酮名称

[ CAS 号 ]:
67392-87-4

[ 中文名 ]:
屈螺酮

[ 英文名 ]:
Drospirenone

[中文别名 ]:

二氢螺利酮

[英文别名 ]:

arbolactone
Drospirenona
Drospirenone
Drospirenon
6b,7b
Dorospirenone
1,2-Dihydrospirorenone
ZK 3059
YASMIN
dihydrospirorenone

屈螺酮生物活性

[ 描述 ]:

Drospirenone(Dihydrospirorenone)是合成的孕酮,是spironolactone的类似物。

[ 相关类别 ]:

信号通路 >> 其他 >> 孕激素受体

研究领域 >> 内分泌

[参考文献]

[1]. Fuhrmann, U., et al., The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception, 1996. 54(4): p. 243-51.

[2]. Muhn, P., et al., Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models. Contraception, 1995. 51(2): p. 99-110.

[3]. Warming, L., et al., Safety and efficacy of drospirenone used in a continuous combination with 17beta-estradiol for prevention of postmenopausal osteoporosis. Climacteric, 2004. 7(1): p. 103-11.

[相关活性小分子]

屈螺酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
552.2±50.0 °C at 760 mmHg

[ 熔点 ]:
196-200ºC

[ 分子式 ]:
C₂₄H₃₀O₃

[ 分子量 ]:
366.493

[ 闪点 ]:
241.6±30.2 °C

[ 精确质量 ]:
366.219482

[ PSA ]:
43.37000

[ LogP ]:
3.15

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.610

[ 储存条件 ]:
0-10°C;避免加热

屈螺酮MSDS

详细MSDS(安全技术说明书)

屈螺酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1299000

CAS REGISTRY NUMBER :: 67392-87-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H30-O3

MOLECULAR WEIGHT :: 366.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1200 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,459,1985

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屈螺酮安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
WH1299000

[ 海关编码 ]:
2937290090

屈螺酮海关

[ 海关编码 ]: 2937290090

屈螺酮文献

Postural tachycardia syndrome (POTS).

Circulation 127(23) , 2336-42, (2013)

Sexual function, mood and menopause symptoms in Lithuanian postmenopausal women.

Climacteric 16(1) , 185-93, (2013)

To assess sexual function in a clinical sample of Lithuanian postmenopausal women and identify the most important determinants of sexual function, including the use of hormone replacement therapy (HT)...

Liquid chromatography with diode array detection and multivariate curve resolution for the selective and sensitive quantification of estrogens in natural waters.

Anal. Chim. Acta 835 , 19-28, (2014)

Following the green analytical chemistry principles, an efficient strategy involving second-order data provided by liquid chromatography (LC) with diode array detection (DAD) was applied for the simul...

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屈螺酮