己酸各司孕甾醇
己酸各司孕甾醇用途
Gestonorone Capronate是治疗良性前列腺肥大和子宫内膜癌的孕激素。
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己酸各司孕甾醇名称
[ CAS 号 ]:
1253-28-7
[ 中文名 ]:
己酸各司孕甾醇
[ 英文名 ]:
Gestonorone Capronate
[中文别名 ]:
[英文别名 ]:
- Gestronol hexanoate
- Depostat
- 17-hexanoyloxy-19-nor-pregn-4-ene-3,20-dione
- Primostat
- 17-Hexanoyloxy-19-nor-pregn-4-en-3,20-dion
- Depostat (TN)
- Gestronol caproate
- ZK 5623
- SH 582
- Gestonorone Capronate
己酸各司孕甾醇生物活性
[ 描述 ]:
Gestonorone Capronate是治疗良性前列腺肥大和子宫内膜癌的孕激素。
[ 相关类别 ]:
[体外研究]
给予孕二烯酮青蒿素可以减少睾酮的减少。氧化途径仍未受到影响。这种对5α-还原产物形成的抑制作用存在于最低剂量的孕甾酮青蒿酸盐中,随着孕甾酮蛋白酸盐浓度的增加而逐渐增加[1]。
[参考文献]
[相关活性小分子]
己酸各司孕甾醇物理化学性质
[ 密度 ]:
1.11g/cm3
[ 沸点 ]:
535.4ºC at 760mmHg
[ 熔点 ]:
123-124°
[ 分子式 ]:
C26H38O4
[ 分子量 ]:
414.57800
[ 闪点 ]:
228.4ºC
[ 精确质量 ]:
414.27700
[ PSA ]:
60.44000
[ LogP ]:
5.57950
[ 蒸汽压 ]:
1.54E-11mmHg at 25°C
[ 折射率 ]:
1.534
[ 储存条件 ]:
-20°C，密闭，干燥
己酸各司孕甾醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC8960700
- CHEMICAL NAME :
- 19-Norpregn-4-ene-3,20-dione, 17-hydroxy-, hexanoate
- CAS REGISTRY NUMBER :
- 1253-28-7
- LAST UPDATED :
- 199210
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C26-H38-O4
- MOLECULAR WEIGHT :
- 414.64
- WISWESSER LINE NOTATION :
- L E5 B666 OV MUTJ E1 FV1 FOV5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Liver - other changes
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Liver - other changes Blood - changes in spleen
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3500 mg/kg/28W-I
- TOXIC EFFECTS :
- Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,307,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 gm/kg/30D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,275,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2520 mg/kg/28W-I
- TOXIC EFFECTS :
- Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,307,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 540 mg/kg/35D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,275,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg/30D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in prostate weight
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,275,1978
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己酸各司孕甾醇上下游产品
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公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
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联系人：徐经理
产品详情：Gestonorone Capronate (Gestonorone caproate)
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥5187.0/5mg
联系人：夏言
产品详情：[Perfemiker]Gestonorone Capronate (Gestonorone caproate),98%
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥4062.0/500mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
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产品详情：己酸己酮
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