无活菌素来源于灰色链霉菌变种

无活菌素来源于灰色链霉菌变种用途

Nonactin 来源于 Streptomyces griseus, 是一种抗生素,作为 K+ 和 NH4+ 载体。Nonactin 是一种氧化磷酸化解偶联剂。Nonactin 选择性诱导含突变 β-catenin 的细胞凋亡。Nonactin 抑制内源性 HSP60 表面表达。

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无活菌素来源于灰色链霉菌变种名称

[ CAS 号 ]:
6833-84-7

[ 中文名 ]:
铵离子载体 I

[ 英文名 ]:
nonactin

[中文别名 ]:

[英文别名 ]:

nonactin
EINECS 229-911-3

无活菌素来源于灰色链霉菌变种生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

[参考文献]

[1]. Martínez-Haya B, et al. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017 Jan 4;19(2):1288-1297.

[2]. Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108(4):772-784.

[3]. Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62(5):1541-8.

无活菌素来源于灰色链霉菌变种物理化学性质

[ 密度 ]:
1.041 g/cm3

[ 沸点 ]:
890.6ºC at 760 mmHg

[ 熔点 ]:
147-148°

[ 分子式 ]:
C₄₀H₆₄O₁₂

[ 分子量 ]:
736.92900

[ 闪点 ]:
352.7ºC

[ 精确质量 ]:
736.44000

[ PSA ]:
142.12000

[ LogP ]:
6.02200

[ 外观性状 ]:
white to faint yellow

[ 折射率 ]:
1.452

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: soluble10mg/mL

无活菌素来源于灰色链霉菌变种MSDS

无活菌素来源于灰色链霉菌变种安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RH1685000

[ 海关编码 ]:
29321900

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无活菌素来源于灰色链霉菌变种文献

Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI.

J. Antibiot. 63(8) , 524-9, (2010)

Precursor-directed biogenetic approach was used to produce a range of nonactin homologues in a 50 l fermentor cultivation of strain Streptomyces griseus 34/249 obtained by UV mutagenesis. The producti...

Synthesis of nonactin and the proposed structure of trilactone.

Org. Lett. 8(13) , 2831-4, (2006)

[reaction: see text] An efficient enantioselective route to nonactin using a novel beta-inversion of an Evans syn aldol to construct the THF ring is presented. Through total synthesis, the structure f...

Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.

Org. Lett. 8(3) , 443-5, (2006)

[reaction: see text]. An efficient resolution of methyl nonactate is reported by biotransformation in shake flask cultures of Rhodococcus erythropolis. The equilibrium of the reaction redox system can...

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